General Information of Drug Therapeutic Target (DTT) (ID: TTB6UM0)

DTT Name Fatty aldehyde dehydrogenase (ALDH3A2)
Synonyms Microsomal aldehyde dehydrogenase; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10; ALDH10
Gene Name ALDH3A2
DTT Type
Successful target
[1]
BioChemical Class
Aldehyde/oxo donor oxidoreductase
UniProt ID
AL3A2_HUMAN
TTD ID
T65291
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.2.1.3
Sequence
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY
Function
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
KEGG Pathway
Glycolysis / Gluconeogenesis (hsa00010 )
Ascorbate and aldarate metabolism (hsa00053 )
Fatty acid degradation (hsa00071 )
Valine, leucine and isoleucine degradation (hsa00280 )
Lysine degradation (hsa00310 )
Arginine and proline metabolism (hsa00330 )
Histidine metabolism (hsa00340 )
Tryptophan metabolism (hsa00380 )
beta-Alanine metabolism (hsa00410 )
Glycerolipid metabolism (hsa00561 )
Pyruvate metabolism (hsa00620 )
Pantothenate and CoA biosynthesis (hsa00770 )
Metabolic pathways (hsa01100 )
Biosynthesis of cofactors (hsa01240 )
Alcoholic liver disease (hsa04936 )
Reactome Pathway
Alpha-oxidation of phytanate (R-HSA-389599 )
Class I peroxisomal membrane protein import (R-HSA-9603798 )
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523 )
RND2 GTPase cycle (R-HSA-9696270 )
RND1 GTPase cycle (R-HSA-9696273 )
Sphingolipid de novo biosynthesis (R-HSA-1660661 )
BioCyc Pathway
MetaCyc:HS01061-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [1]
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1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
NPS 1776 DM0CF3B Epilepsy 8A60-8A68 Discontinued in Phase 2 [2]
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3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aloe-emodin DMPTY8S Discovery agent N.A. Investigative [3]
NSC-527035 DMY689Z Discovery agent N.A. Investigative [4]
S-methyl 4-methyl-4-morpholinopent-2-ynethioate DM79QC2 Discovery agent N.A. Investigative [5]
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References

1 Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther. 2006 Sep;111(3):855-76.
2 Diverse Mechanisms of Antiepileptic Drugs in the Development Pipeline. Epilepsy Res. 2006 June; 69(3): 273-294.
3 Elgonica-Dimers A and B, Two Potent Alcohol Metabolism Inhibitory Constituents of Aloe arborescens J. Nat. Prod. 60(11):1180-1182 (1997).
4 Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast... J Med Chem. 2010 Apr 8;53(7):2757-65.
5 Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but i... Eur J Med Chem. 2008 May;43(5):906-16.