General Information of Drug Therapeutic Target (DTT) (ID: TTC67I0)

DTT Name Bacterial Glucosamine-6-phosphate synthase (Bact glmS)
Synonyms glmS; L-glutamine-D-fructose-6-phosphate amidotransferase; Hexosephosphate aminotransferase; Glucosamine--fructose-6-phosphate aminotransferase; GFAT; D-fructose-6-phosphate amidotransferase
Gene Name Bact glmS
DTT Type
Clinical trial target
[1]
BioChemical Class
Transaminase
UniProt ID
GLMS_ECOLI
TTD ID
T12409
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.6.1.16
Sequence
MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAE
EHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGIIENHEPLREELKARGYTFV
SETDTEVIAHLVNWELKQGGTLREAVLRAIPQLRGAYGTVIMDSRHPDTLLAARSGSPLV
IGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQ
YDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILA
CGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGL
RLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKL
SRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIA
LEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR
GGQLYVFADQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPR
NLAKSVTVE
Function Catalyzesthe first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
KEGG Pathway
Alanine, aspartate and glutamate metabolism (ecj00250 )
Amino sugar and nucleotide sugar metabolism (ecj00520 )
Metabolic pathways (ecj01100 )
Biosynthesis of nucleotide sugars (ecj01250 )
BioCyc Pathway
MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-MON
EcoCyc:L-GLN-FRUCT-6-P-AMINOTRANS-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glucose-6-Phosphate DMKY1L4 N. A. N. A. Phase 1 [1]
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7 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB Discovery agent N.A. Investigative [1]
2-Deoxy-2-Amino Glucitol-6-Phosphate DMBMK4T Discovery agent N.A. Investigative [1]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [1]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [1]
Alpha-D-Glucose-6-Phosphate DMR0EVN Discovery agent N.A. Investigative [1]
Glucosamine 6-Phosphate DMY590Q Discovery agent N.A. Investigative [1]
Glutamine Hydroxamate DMT7K0U Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 7 Investigative Drug(s)

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.