Details of the Drug

General Information of Drug (ID: DMKY1L4)

Drug Name
Glucose-6-Phosphate
Synonyms
Robison ester; Glucose 6-phosphate; 6-O-phosphono-D-glucopyranose; D-glucopyranose 6-phosphate; D-glucopyranose, 6-(dihydrogen phosphate); Glucose 6-(dihydrogen phosphate); 299-31-0; {[(2R,3S,4S,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid; D-glucose-6P; Glc6P; D-glucose-6-P; a-D-glucose 6- phosphate; AC1L1LI0; SCHEMBL48379; CHEBI:4170; GTPL4647; AC1Q28E3; D-Glucopyranose 6-phosphoric acid
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 260.14
Logarithm of the Partition Coefficient (xlogp) -4.2
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 6
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C6H13O9P
IUPAC Name
[(2R,3S,4S,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
Canonical SMILES
C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)O)O)O)OP(=O)(O)O
InChI
InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6?/m1/s1
InChIKey
NBSCHQHZLSJFNQ-GASJEMHNSA-N
Cross-matching ID
PubChem CID
5958
ChEBI ID
CHEBI:4170
CAS Number
299-31-0
DrugBank ID
DB03581
TTD ID
D05TIS
VARIDT ID
DR00098

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Glucosamine-6-phosphate synthase (Bact glmS) TTC67I0 GLMS_ECOLI Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Glucose-6-phosphate translocase (SLC37A4) DTLHZFU G6PT1_HUMAN Substrate [2]
Glycerol-3-phosphate permease (SLC37A1) DTH9SQJ G6PT2_HUMAN Substrate [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 A novel mutation (A148V) in the glucose 6-phosphate translocase (SLC37A4) gene in a Korean patient with glycogen storage disease type 1b. J Korean Med Sci. 2005 Jun;20(3):499-501.
3 SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157.