General Information of Drug Therapeutic Target (DTT) (ID: TTCI43M)

DTT Name GABA(A) receptor (GABAR)
Gene Name GABAR
DTT Type
Clinical trial target
[1]
UniProt ID
NOUNIPROTAC
TTD ID
T84457

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ganaxolone DMXJMKF Epileptic seizures 8A61-8A6Z Approved [2]
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6 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
OV101 DMA6LR3 Angelman syndrome LD90.0 Phase 3 [3]
PH94B NS DMDC7OH Social anxiety disorder 6B04 Phase 3 [4]
Padsevonil DMRZ1F2 Epilepsy 8A60-8A68 Phase 2/3 [5]
BTD-001 DMS6ZA0 Narcolepsy 7A20 Phase 2 [6]
Evt201 DM8QXEY Sleep-wake disorder 7A00-7B2Z Phase 2 [7]
SAGE-324 DM5NC39 Essential tremor or related tremors 8A04.1 Phase 2 [1]
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⏷ Show the Full List of 6 Clinical Trial Drug(s)

References

1 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215904.
3 Gaboxadol in Fragile X Syndrome: A 12-Week Randomized, Double-Blind, Parallel-Group, Phase 2a Study. Front Pharmacol. 2021 Oct 8;12:757825.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 The partial positive allosteric GABA(A) receptor modulator EVT 201 is efficacious and safe in the treatment of adult primary insomnia patients. Sleep Med. 2009 Sep;10(8):859-64.