Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCV6O0)

DTT Name	Endothelin receptor (EDNR) DTT Info
Gene Name	EDNR

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Clinical Trial Drug(s)

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2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clazosentan	DMQSBX4	Cerebral vasospasm	BA85.Z	Phase 3	[1]
Aprocitentan	DMEJICQ	Hypertension	BA00-BA04	Phase 2	[1]
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2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TAK-044	DMBQ87R	Renal failure	GB60-GB6Z	Discontinued in Phase 2	[2]
Ro-46-2005	DMRT6FV	Hypertension	BA00-BA04	Terminated	[3]
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Molecule Interaction Atlas

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Pharmacology of a non-selective ETA and ETB receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br J Pharmacol. 1995 Mar;114(5):949-54.
3	In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors. FEBS Lett. 1993 Nov 15;334(2):210-4.