Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTES57P)

DTT Name	Branched-chain-amino-acid transaminase 1 (BCAT1)
Synonyms	Protein ECA39; ECA39; Branched-chain-amino-acid aminotransferase, cytosolic; BCT1; BCAT(c)
Gene Name	BCAT1
DTT Type	Literature-reported target	[1]
BioChemical Class	Transaminase
UniProt ID	BCAT1_HUMAN
TTD ID	T92557
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.6.1.42
Sequence	MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTV EWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRM YRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTK ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDN GCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQ WGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPK LASRILSKLTDIQYGREESDWTIVLS
Function	Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
KEGG Pathway	Cysteine and methionine metabolism (hsa00270 ) Valine, leucine and isoleucine degradation (hsa00280 ) Valine, leucine and isoleucine biosynthesis (hsa00290 ) Pantothenate and CoA biosynthesis (hsa00770 ) Metabolic pathways (hsa01100 ) 2-Oxocarboxylic acid metabolism (hsa01210 ) Biosynthesis of amino acids (hsa01230 )
Reactome Pathway	Branched-chain amino acid catabolism (R-HSA-70895 )

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Cytosolic branched aminotransferase (BCAT1) DME Info

Gene Name

BCAT1

1 Investigative Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-valine	DM68RPD	Discovery agent	N.A.	Investigative	[2]
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References

1	Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid... Mol Divers. 2009 Nov;13(4):493-500.
2	Purification, crystallization and preliminary X-ray crystallographic analysis of branched-chain aminotransferase from Deinococcus radiodurans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):492-4.