Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTF23ML)

DTT Name Glial cell line-derived neurotrophic factor (GDNF)
Synonyms hGDNF; Glial cell linederived neurotrophic factor; Astrocytederived trophic factor; Astrocyte-derived trophic factor; ATF
Gene Name GDNF
DTT Type
Clinical trial target
 [1]
BioChemical Class
Growth factor
UniProt ID
GDNF_HUMAN
TTD ID
T79160
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ
FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL
TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR
PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
KEGG Pathway
Calcium signaling pathway (hsa04020 )
Reactome Pathway
RAF/MAP kinase cascade (R-HSA-5673001 )
RET signaling (R-HSA-8853659 )
NCAM1 interactions (R-HSA-419037 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Liatermin DMENF5K Lateral sclerosis 8B61 Phase 1/2 [1]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Lateral sclerosis 8A00.0 Cervical spinal cord 2.29E-01 0.08 0.31
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References

1 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.