Details of the Drug

General Information of Drug (ID: DMENF5K)

Drug Name

Liatermin

Synonyms

RGDNF; GDNF, Amgen; Glial derived neurotrophic factor, Amgen/Medtronic

Indication

Disease Entry	ICD 11	Status	REF
Lateral sclerosis	8B61	Phase 1/2	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glial cell line-derived neurotrophic factor (GDNF)	TTF23ML	GDNF_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

ICD Disease Classification

08 Disease of the nervous system

Disease Class

ICD-11: 8A00 Parkinsonism

The Studied Tissue

Cervical spinal cord

The Studied Disease

Lateral sclerosis [ICD-11:8A00.0]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glial cell line-derived neurotrophic factor (GDNF)	DTT	GDNF	2.29E-01	0.08	0.31

Molecular Expression Atlas (MEA)

Jump to Detail Molecular Expression Atlas of This Drug

References

1	ClinicalTrials.gov (NCT00111982) Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have Completed a Previous Trial of Liatermin. U.S. National Institutes of Health.
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.