Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFSX6G)

DTT Name Bacterial MTA/SAH nucleosidase (Bact mtnN)
Synonyms mtnN; S-adenosylhomocysteine nucleosidase; P46; 5'-methylthioadenosine nucleosidase; 5'-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase
Gene Name Bact mtnN
DTT Type
Literature-reported target
 [1]
BioChemical Class
Glycosylase
UniProt ID
MTNN_ECOLI
TTD ID
T70521
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK
ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH
VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
Function
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n- butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza- adenosylhomocysteine as substrates.
KEGG Pathway
Cysteine and methionine metabolism (ecj00270 )
Metabolic pathways (ecj01100 )
Biosynthesis of amino acids (ecj01230 )
BioCyc Pathway
MetaCyc:EG11090-MON
EcoCyc:EG11090-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
5'-Deoxy-5'-(Methylthio)-Tubercidin DMR28HG Discovery agent N.A. Investigative [1]
Formycin DMWG0P3 Discovery agent N.A. Investigative [1]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.