General Information of Drug Therapeutic Target (DTT) (ID: TTI6V2A)

DTT Name Heme oxygenase 1 (HMOX1)
Synonyms HO1; HO-1; HO
Gene Name HMOX1
DTT Type
Clinical trial target
[1]
BioChemical Class
Paired donor oxygen oxidoreductase
UniProt ID
HMOX1_HUMAN
TTD ID
T25703
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.14.14.18
Sequence
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
Function
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
KEGG Pathway
Porphyrin and chlorophyll metabolism (hsa00860 )
HIF-1 signaling pathway (hsa04066 )
Mineral absorption (hsa04978 )
MicroRNAs in cancer (hsa05206 )
Reactome Pathway
Iron uptake and transport (R-HSA-917937 )
BioCyc Pathway
MetaCyc:HS02027-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Stannsoporfin DMEG4TC Neonatal hyperbilirubinemia KA87 Phase 2 [1]
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9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone DMOTJWZ Discovery agent N.A. Investigative [2]
12-Phenylheme DMLR2FB Discovery agent N.A. Investigative [3]
2-Phenylheme DMPIQTE Discovery agent N.A. Investigative [3]
2-Propanol, Isopropanol DML5O0H Discovery agent N.A. Investigative [3]
Biliverdine Ix Alpha DMCA0WJ N. A. N. A. Investigative [3]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [3]
Heme DMGC287 Discovery agent N.A. Investigative [2]
Tin protoporphyrin DMTXJ5S Discovery agent N.A. Investigative [4]
Verdoheme DM7NRK5 Discovery agent N.A. Investigative [5]
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⏷ Show the Full List of 9 Investigative Drug(s)

References

1 Chemoprevention of severe neonatal hyperbilirubinemia. Semin Perinatol. 2004 Oct;28(5):365-8.
2 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4 Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation. Circulation. 2001 Nov 27;104(22):2710-5.
5 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.