Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIJ5EB)

• DTT Name: Bacterial RNA polymerase switch region (Bact RNAP-SR)
• Gene Name: NO-GeName
• DTT Type: Successful target; [1]
• Related Disease:
  Clostridium difficile enterocolitis [ICD-11: 1A04]
  HIV-infected patients with tuberculosis [ICD-11: 1B10-1B14]
• UniProt ID: NOUNIPROTAC
• TTD ID: T30520

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fidaxomicin	DMFP6MV	Clostridium difficile associated diarrhea	1A04	Approved	[2]
Rifampin	DMA8J1G	Tuberculosis	1B10-1B1Z	Approved	[1], [3]

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifalazil	DMYXOHV	Bacterial infection	1A00-1C4Z	Phase 3	[4]

References

• [1] Bacillus subtilis tolerance of moderate concentrations of rifampin involves the sigma(B)-dependent general and multiple stress response. J Bacteriol. 2002 Jan;184(2):459-67.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
• [4] Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.