Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIJ5EB)

DTT Name	Bacterial RNA polymerase switch region (Bact RNAP-SR)
Gene Name	Bact RNAP-SR
DTT Type	Successful target	[1]
UniProt ID	NOUNIPROTAC
TTD ID	T30520

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fidaxomicin	DMFP6MV	Clostridioides difficile infection	1A04	Approved	[2]
Rifampin	DMA8J1G	Tuberculosis	1B10-1B1Z	Approved	[1]
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1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifalazil	DMYXOHV	Bacterial infection	1A00-1C4Z	Phase 3	[3]
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References

1	Bacillus subtilis tolerance of moderate concentrations of rifampin involves the sigma(B)-dependent general and multiple stress response. J Bacteriol. 2002 Jan;184(2):459-67.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.