General Information of Drug (ID: DMFP6MV)

Drug Name
Fidaxomicin
Synonyms Dificid (TN)
Indication
Disease Entry ICD 11 Status REF
Clostridioides difficile infection 1A04 Approved [1]
Clostridium difficile associated diarrhea 1A04 Approved [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 5 Molecular Weight (mw) 1058
Logarithm of the Partition Coefficient (xlogp) 6.4
Rotatable Bond Count (rotbonds) 15
Hydrogen Bond Donor Count (hbonddonor) 7
Hydrogen Bond Acceptor Count (hbondacc) 18
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 5.20 +/- 2.81 mcg/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2 h [3]
Elimination
More than 92% of the dose was recovered in the faces as either the unchanged parent drug or metabolites in one study consisting of healthy adults receiving single doses of 200 mg and 300 mg of fidaxomicin [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 11.7 +/- 4.80 hours (in healthy adults with a single dose of 200 mg fidaxomicin) [3]
Metabolism
The drug is metabolized via the hydrolysis at the isobutyryl ester [4]
Chemical Identifiers
Formula
C52H74Cl2O18
IUPAC Name
[(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate
Canonical SMILES
CC[C@H]1/C=C(/[C@H](C/C=C/C=C(/C(=O)O[C@@H](C/C=C(/C=C(/[C@@H]1O[C@H]2[C@H]([C@H]([C@@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\\C)\\C)[C@@H](C)O)\\CO[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)\\C
InChI
InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1
InChIKey
ZVGNESXIJDCBKN-UUEYKCAUSA-N
Cross-matching ID
PubChem CID
10034073
CAS Number
873857-62-6
DrugBank ID
DB08874
TTD ID
D06LNW
VARIDT ID
DR00545
ACDINA ID
D00274
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial RNA polymerase switch region (Bact RNAP-SR) TTIJ5EB NOUNIPROTAC Modulator [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Fidaxomicin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Sarecycline DMLZNIQ Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Sarecycline . Acne vulgaris [ED80] [6]
Arn-509 DMT81LZ Moderate Increased metabolism of Fidaxomicin caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [7]
Gilteritinib DMTI0ZO Moderate Decreased metabolism of Fidaxomicin caused by Gilteritinib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [7]
Troleandomycin DMUZNIG Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Troleandomycin. Bacterial infection [1A00-1C4Z] [6]
Erdafitinib DMI782S Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Erdafitinib. Bladder cancer [2C94] [8]
Pexidartinib DMS2J0Z Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [6]
Talazoparib DM1KS78 Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [6]
HKI-272 DM6QOVN Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by HKI-272. Breast cancer [2C60-2C6Y] [6]
Tucatinib DMBESUA Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Tucatinib. Breast cancer [2C60-2C6Y] [9]
PF-04449913 DMSB068 Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by PF-04449913. Chronic myelomonocytic leukaemia [2A40] [9]
Ripretinib DM958QB Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Ripretinib. Gastrointestinal stromal tumour [2B5B] [6]
Daclatasvir DMSFK9V Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Daclatasvir. Hepatitis virus infection [1E50-1E51] [6]
GS-5885 DMSL3DX Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by GS-5885. Hepatitis virus infection [1E50-1E51] [6]
Berotralstat DMWA2DZ Major Decreased clearance of Fidaxomicin due to the transporter inhibition by Berotralstat. Innate/adaptive immunodeficiency [4A00] [6]
Suvorexant DM0E6S3 Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Suvorexant. Insomnia [7A00-7A0Z] [6]
Brigatinib DM7W94S Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Brigatinib. Lung cancer [2C25] [6]
Capmatinib DMYCXKL Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Capmatinib. Lung cancer [2C25] [9]
GDC-0199 DMH0QKA Major Decreased clearance of Fidaxomicin due to the transporter inhibition by GDC-0199. Mature B-cell leukaemia [2A82] [6]
Ibrutinib DMHZCPO Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Ibrutinib. Mature B-cell lymphoma [2A85] [7]
Ponatinib DMYGJQO Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Ponatinib. Mature B-cell lymphoma [2A85] [6]
Arry-162 DM1P6FR Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Arry-162. Melanoma [2C30] [6]
Lasmiditan DMXLVDT Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Lasmiditan. Migraine [8A80] [10]
Rolapitant DM8XP26 Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Rolapitant. Nausea/vomiting [MD90] [6]
Istradefylline DM20VSK Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Istradefylline. Parkinsonism [8A00] [6]
Enzalutamide DMGL19D Moderate Accelerated clearance of Fidaxomicin due to the transporter induction by Enzalutamide. Prostate cancer [2C82] [11]
Relugolix DMK7IWL Major Decreased clearance of Fidaxomicin due to the transporter inhibition by Relugolix. Prostate cancer [2C82] [6]
Larotrectinib DM26CQR Moderate Decreased metabolism of Fidaxomicin caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [6]
Fostamatinib DM6AUHV Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [12]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Fidaxomicin due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [13]
Cabozantinib DMIYDT4 Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Cabozantinib. Thyroid cancer [2D10] [6]
Elagolix DMB2C0E Minor Decreased clearance of Fidaxomicin due to the transporter inhibition by Elagolix. Uterine fibroid [2E86] [6]
⏷ Show the Full List of 31 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Butylated hydroxytoluene E00336 31404 Antioxidant
Magnesium stearate E00208 11177 lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 6 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Fidaxomicin 200 mg tablet 200 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Fidaxomicin FDA Label
2 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
3 FDA Approved Drug Products: DIFICID (fidaxomicin) tablets, for oral use
4 Russell RG, Watts NB, Ebetino FH, Rogers MJ: Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 2008 Jun;19(6):733-59. doi: 10.1007/s00198-007-0540-8.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 Cerner Multum, Inc. "Australian Product Information.".
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
9 Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
10 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
11 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
12 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
13 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".