General Information of Drug Therapeutic Target (DTT) (ID: TTJCOQ7)

DTT Name Ceroid-lipofuscinosis neuronal protein 6 (CLN6)
Synonyms Protein CLN6
Gene Name CLN6
DTT Type
Clinical trial target
[1]
UniProt ID
CLN6_HUMAN
TTD ID
T63191
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDF
GRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIF
IMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCM
WYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFA
MLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPW
AFYTLHVSSRH
KEGG Pathway
54982 (hsa )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
AT-GTX-501 DMGKYAE CLN6 disease 5C56.1 Phase 1/2 [1]
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References

1 ClinicalTrials.gov (NCT02725580) Phase I/IIa Gene Transfer Clinical Trial for Variant Late Infantile Neuronal Ceroid Lipofuscinosis, Delivering the CLN6 Gene by Self-Complementary AAV9. U.S.National Institutes of Health.