Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTKGEP3)

• DTT Name: Glutamic acid decarboxylase 1 (GAD1)
• Synonyms: Glutamate decarboxylase 67 kDa isoform; Glutamate decarboxylase 1; GAD67; GAD-67; GAD; 67 kDa glutamic acid decarboxylase
• Gene Name: GAD1
• DTT Type: Literature-reported target; [1]
• UniProt ID: DCE1_HUMAN
• TTD ID: T26900
• EC Number: EC 4.1.1.15
• Sequence:
  MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
  SRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
  VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
  RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
  SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAA
  LGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA
  DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE
  KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
  NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP
  KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL
• Function: Catalyzes the production of GABA.
• KEGG Pathway:
  Alanine, aspartate and glutamate metabolism (hsa00250)
  beta-Alanine metabolism (hsa00410)
  Taurine and hypotaurine metabolism (hsa00430)
  Butanoate metabolism (hsa00650)
  Metabolic pathways (hsa01100)
  GABAergic synapse (hsa04727)
  Type I diabetes mellitus (hsa04940)
• Reactome Pathway:
  GABA synthesis, release, reuptake and degradation (R-HSA-888590)
  MECP2 regulates transcription of genes involved in GABA signaling (R-HSA-9022927)
  GABA synthesis (R-HSA-888568)
• BioCyc Pathway: MetaCyc:HS05215-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AAV-GAD	DMOOY9W	Parkinson disease	8A00.0	Phase 2	[2]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
s-allylglycine	DMUPCA6	Discovery agent	N.A.	Investigative	[1]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1272).
• [2] Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet. 2007 Jun 23;369(9579):2097-105.