Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLJKZ0)

DTT Name Acetyl-CoA transporter (SLC33A1)
Synonyms Solute carrier family 33 member 1; Acetyl-coenzyme A transporter 1; Acetyl-CoA transporter 1; AT1 protein; AT-1; ACATN
Gene Name SLC33A1
DTT Type
Patented-recorded target
 [1]
BioChemical Class
Major facilitator
UniProt ID
ACATN_HUMAN
TTD ID
T11791
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD
FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS
LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT
VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL
LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP
LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL
HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS
SSWKCKRNN
Function Negatively regulates BMP signaling. Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.
KEGG Pathway
Glycosphingolipid biosynthesis - ganglio series (hsa00604 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Defective SLC33A1 causes spastic paraplegia 42 (SPG42) (R-HSA-5619061 )
Transport of vitamins, nucleosides, and related molecules (R-HSA-425397 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
US8592431, 181 DM29KS1 N. A. N. A. Patented [2]
US8592431, 185 DM1K5HS N. A. N. A. Patented [2]
US8592431, 457 DMAPGBF N. A. N. A. Patented [2]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]acetylCoA DM42B5D Discovery agent N.A. Investigative [1]
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name Acetyl-coenzyme A transporter 1 (SLC33A1) DTP Info
Gene Name SLC33A1

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1134).
2 Fused ring compound and use thereof. US8592431.