General Information of Drug Therapeutic Target (DTT) (ID: TTLSWP6)

DTT Name GTP cyclohydrolase-I (GCH1)
Synonyms Guanosine triphosphate cyclohydrolase I; GTP-CH-I; GTP cyclohydrolase I; GTP cyclohydrolase 1; GCH; DYT5
Gene Name GCH1
DTT Type
Clinical trial target
[1]
BioChemical Class
Carbon-nitrogen hydrolase
UniProt ID
GCH1_HUMAN
TTD ID
T28226
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 3.5.4.16
Sequence
MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRS
EEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDA
IFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQ
VQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKT
REEFLTLIRS
Function
May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs).
KEGG Pathway
Folate biosynthesis (hsa00790 )
Metabolic pathways (hsa01100 )
Biosynthesis of cofactors (hsa01240 )
Reactome Pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (R-HSA-1474151 )
BioCyc Pathway
MetaCyc:HS05586-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanine DMIWLJE N. A. N. A. Phase 3 [1]
OXB-102 DMXF9DM Parkinson disease 8A00.0 Phase 1/2 [2]
ProSavin DMJ42E6 Parkinson disease 8A00.0 Phase 1/2 [3]
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3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Propanol, Isopropanol DML5O0H Discovery agent N.A. Investigative [4]
8-hydroxyguanine DMT9BPN Discovery agent N.A. Investigative [1]
Guanosine-5'-Triphosphate DMV2OJX Discovery agent N.A. Investigative [5]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Parkinson's disease 8A00.0 Substantia nigra tissue 3.38E-02 -1.59 -1.53
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References

1 GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73.
2 Clinical pipeline report, company report or official report of Oxford BioMedica.
3 Clinical pipeline report, company report or official report of Oxford BioMedica.
4 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.