Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTLSWP6)

• DTT Name: GTP cyclohydrolase-I (GCH1) DTT Info
• Gene Name: GCH1

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanine	DMIWLJE	N. A.	N. A.	Phase 3	[1]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[2]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[3]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[4]
8-hydroxyguanine	DMT9BPN	Discovery agent	N.A.	Investigative	[1]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[5]

References

• [1] GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73.
• [2] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [3] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [4] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.