Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTM6HK1)

DTT Name	Hemoglobin subunit beta (HBB)
Synonyms	LVVhemorphin7; Hemoglobin beta chain; Betaglobin; Beta-globin
Gene Name	HBB
DTT Type	Clinical trial target	[1]
BioChemical Class	Pore-forming globin
UniProt ID	HBB_HUMAN
TTD ID	T31825
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG KEFTPPVQAAYQKVVAGVANALAHKYH
Function	Involved in oxygen transport from the lung to the various peripheral tissues.
KEGG Pathway	African trypanosomiasis (hsa05143 ) Malaria (hsa05144 )
Reactome Pathway	Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673 ) Scavenging of heme from plasma (R-HSA-2168880 ) Factors involved in megakaryocyte development and platelet production (R-HSA-983231 ) Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LentiGlobin	DMSCGM8	Beta thalassemia	3A50.2	Phase 3	[1]
OTL-300	DMYGK1D	Beta thalassemia	3A50.2	Phase 1/2	[2]
PF-07059013	DMSDVKK	Sickle-cell disorder	3A51	Phase 1	[3]
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References

1	Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of beta-thalassemia and sickle cell disease. Curr Gene Ther. 2015;15(1):64-81.
2	Clinical pipeline report, company report or official report of Orchard Therapeutics.
3	PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease. Am J Hematol. 2021 Aug 1;96(8):E272-E275.