Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTM6HK1)

DTT Name	Hemoglobin subunit beta (HBB) DTT Info
Gene Name	HBB

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

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3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LentiGlobin	DMSCGM8	Beta thalassemia	3A50.2	Phase 3	[1]
OTL-300	DMYGK1D	Beta thalassemia	3A50.2	Phase 1/2	[2]
PF-07059013	DMSDVKK	Sickle-cell disorder	3A51	Phase 1	[3]
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Molecule Interaction Atlas

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References

1	Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of beta-thalassemia and sickle cell disease. Curr Gene Ther. 2015;15(1):64-81.
2	Clinical pipeline report, company report or official report of Orchard Therapeutics.
3	PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease. Am J Hematol. 2021 Aug 1;96(8):E272-E275.