Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMPART)

DTT Name Uracil nucleotide/cysteinyl leukotriene receptor (GPR17)
Synonyms UDP/CysLT receptor; R12; G-protein coupled receptor 17
Gene Name GPR17
DTT Type
Literature-reported target
 [1]
UniProt ID
GPR17_HUMAN
TTD ID
T33902
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENM
LFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHF
SGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLAC
AFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCY
LLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQ
RILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESS
LSAKSEL
Function
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Reactome Pathway
G alpha (q) signalling events (R-HSA-416476 )
P2Y receptors (R-HSA-417957 )
G alpha (i) signalling events (R-HSA-418594 )
Leukotriene receptors (R-HSA-391906 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ASN02563583 DMEO3Y4 Discovery agent N.A. Investigative [2]
ASN04421891 DMC82XN Discovery agent N.A. Investigative [2]
ASN04450772 DMKR69T Discovery agent N.A. Investigative [2]
ASN04885796 DMQ0VZ8 Discovery agent N.A. Investigative [2]
ASN06917370 DMA20JP Discovery agent N.A. Investigative [2]
LTC4 DM702WR Discovery agent N.A. Investigative [1]
LTD4 DMIUZX3 Discovery agent N.A. Investigative [1]
LTE4 DMCPB0Q Discovery agent N.A. Investigative [3]
UDP-glucose DMLT4JA Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 9 Investigative Drug(s)

References

1 The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27.
2 In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des. 2011 Aug;25(8):743-52.
3 The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One. 2008;3(10):e3579.