| DTT Name |
HUMAN type-1 angiotensin II receptor (AGTR1)
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| Synonyms |
Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; Angiotensin II receptor 1; Angiotensin 1 receptor; AT2R1B; AT2R1; AT1BR; AT1AR; AT1; AGTR1B; AGTR1A |
| Gene Name |
AGTR1
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| BioChemical Class |
GPCR rhodopsin
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| Sequence |
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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| Function |
Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Receptor for angiotensin II. |
| KEGG Pathway |
- Calcium signaling pathway (hsa04020 )
- cGMP-PKG signaling pathway (hsa04022 )
- Phospholipase D signaling pathway (hsa04072 )
- Neuroactive ligand-receptor interaction (hsa04080 )
- Adrenergic signaling in cardiomyocytes (hsa04261 )
- Vascular smooth muscle contraction (hsa04270 )
- Apelin signaling pathway (hsa04371 )
- Renin-angiotensin system (hsa04614 )
- Renin secretion (hsa04924 )
- Aldosterone synthesis and secretion (hsa04925 )
- Cortisol synthesis and secretion (hsa04927 )
- AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
- Cushing syndrome (hsa04934 )
- Coronavirus disease - COVID-19 (hsa05171 )
- Pathways in cancer (hsa05200 )
- Diabetic cardiomyopathy (hsa05415 )
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| Reactome Pathway |
- G alpha (q) signalling events (R-HSA-416476 )
- Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825 )
- Clathrin-mediated endocytosis (R-HSA-8856828 )
- Peptide ligand-binding receptors (R-HSA-375276 )
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