Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTPS279)

• DTT Name: Catalase (CAT)
• Synonyms: Human catalase
• Gene Name: CAT
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Peroxide acceptor oxidoreductase
• UniProt ID: CATA_HUMAN
• TTD ID: T01597
• EC Number: EC 1.11.1.6
• Sequence:
  MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
  MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
  GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
  MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
  GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
  KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
  THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
  HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
  NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
• Function: Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
• KEGG Pathway:
  Tryptophan metabolism (hsa00380)
  Glyoxylate and dicarboxylate metabolism (hsa00630)
  Biosynthesis of antibiotics (hsa01130)
  FoxO signaling pathway (hsa04068)
  Peroxisome (hsa04146)
  Amyotrophic lateral sclerosis (ALS) (hsa05014)
• Reactome Pathway:
  Purine catabolism (R-HSA-74259)
  Detoxification of Reactive Oxygen Species (R-HSA-3299685)
• BioCyc Pathway: MetaCyc:MON66-341

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EUK-189	DMY9ZAS	Skin burns	ME65.0	Phase 1	[1]

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Catalase (CAT) DME Info
• Gene Name: CAT

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcium carbimide	DM3W15N	Alcohol dependence	6C40.2	Approved	[2]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]

References

• [1] Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90.
• [2] Vasiliou V. and Petersen D. (2010). Comprehensive toxicology (2nd ed.). Elsevier.
• [3] Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9.