General Information of Drug (ID: DMY9ZAS)

Drug Name
EUK-189
Synonyms EUK-189 (topical formulation, radiation burns); EUK-189 (topical formulation, radiation burns), Minerva/Proteome; EUK-189 (topicalformulation, radiation burns), Minerva/Tyrian
Indication
Disease Entry ICD 11 Status REF
Skin burns ME65.0 Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0
Molecular Weight 469.4
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 6
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 8
Chemical Identifiers
Formula
C22H26MnN2O6-2
IUPAC Name
acetic acid;2-ethoxy-6-[2-[(3-ethoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate;manganese
Canonical SMILES
CCOC1=CC=CC(=C1[O-])C=NCCN=CC2=C(C(=CC=C2)OCC)[O-].CC(=O)O.[Mn]
InChI
InChI=1S/C20H24N2O4.C2H4O2.Mn/c1-3-25-17-9-5-7-15(19(17)23)13-21-11-12-22-14-16-8-6-10-18(20(16)24)26-4-2;1-2(3)4;/h5-10,13-14,23-24H,3-4,11-12H2,1-2H3;1H3,(H,3,4);/p-2
InChIKey
SZYIPDLZPMRUNA-UHFFFAOYSA-L
Cross-matching ID
PubChem CID
146157762
TTD ID
D06VAQ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Catalase (CAT) TTPS279 CATA_HUMAN Modulator [1]
Superoxide dismutase Cu-Zn (SOD Cu-Zn) TT6RVLG SODC_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90.