Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQ29KF)

• DTT Name: Voltage-gated potassium channel Kv7 (KCNQ)
• Synonyms: Voltage-gated potassium channel subunit Kv7; Potassium voltage-gated channel subfamily KQT; Kv7; KVLQT; KQT-like; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT
• Gene Name: NO-GeName
• DTT Type: Clinical trial target; [1]
• Related Disease: Behcet disease [ICD-11: 4A62]
• BioChemical Class: Voltage-gated ion channel
• UniProt ID: NOUNIPROTAC
• TTD ID: T86192
• KEGG Pathway:
  Adrenergic signaling in cardiomyocytes (hsa04261)
  Cholinergic synapse (hsa04725)
  Gastric acid secretion (hsa04971)
  Pancreatic secretion (hsa04972)
  Protein digestion and absorption (hsa04974)
  Vibrio cholerae infection (hsa05110)

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[2]

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CNSB-001	DM2PEU5	Neuropathic pain	8E43.0	Phase 2	[1]
Flupirtine	DMPBV9D	Cancer related pain	MG30	Phase 2	[3]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DMP-543	DMCNEOZ	Parkinson disease	8A00.0	Discontinued in Phase 2	[4]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Parkinson's disease	8A00.0	Substantia nigra tissue	6.24E-01	0.11	0.85

References

• [1] The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve. J Peripher Nerv Syst. 2010 Mar;15(1):63-72.
• [2] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [3] Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. Br J Pharmacol. 2009 August; 157(7): 1241-1249.
• [4] KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.Pharmacol Res.2011 Oct;64(4):397-409.