Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQ29KF)

• DTT Name: Voltage-gated potassium channel Kv7 (KCNQ) DTT Info
• Gene Name: KCNQ

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[1]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CNSB-001	DM2PEU5	Neuropathic pain	8E43.0	Phase 2	[2]
Flupirtine	DMPBV9D	Cancer related pain	MG30	Phase 2	[3]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DMP-543	DMCNEOZ	Parkinson disease	8A00.0	Discontinued in Phase 2	[4]

References

• [1] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [2] The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve. J Peripher Nerv Syst. 2010 Mar;15(1):63-72.
• [3] Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. Br J Pharmacol. 2009 August; 157(7): 1241-1249.
• [4] KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.Pharmacol Res.2011 Oct;64(4):397-409.