Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQ8J1V)

• DTT Name: Bacterial Deoxy-manno-octulosonate cytidylyltransferase (Bact kdsB)
• Synonyms: kdsB; CMP-KDO synthetase; CMP-2-keto-3-deoxyoctulosonic acid synthetase; CKS; 3-deoxy-D-manno-octulosonate cytidylytransferase
• Gene Name: Bact kdsB
• DTT Type: Clinical trial target; [1]
• Related Disease: Idiopathic inflammatory myopathy [ICD-11: 4A41]
• BioChemical Class: Kinase
• UniProt ID: KDSB_ECOLI
• TTD ID: T66120
• EC Number: EC 2.7.7.38
• Sequence:
  MSFVVIIPARYASTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEA
  AGGEVCMTRADHQSGTERLAEVVEKCAFSDDTVIVNVQGDEPMIPATIIRQVADNLAQRQ
  VGMATLAVPIHNAEEAFNPNAVKVVLDAEGYALYFSRATIPWDRDRFAEGLETVGDNFLR
  HLGIYGYRAGFIRRYVNWQPSPLEHIEMLEQLRVLWYGEKIHVAVAQEVPGTGVDTPEDL
  ERVRAEMR
• Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
• KEGG Pathway:
  Lipopolysaccharide biosynthesis (ecj00540)
  Metabolic pathways (ecj01100)
  Biosynthesis of nucleotide sugars (ecj01250)
• BioCyc Pathway:
  MetaCyc:CPM-KDOSYNTH-MON
  EcoCyc:CPM-KDOSYNTH-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[1]

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cmp-2-Keto-3-Deoxy-Octulosonic Acid	DMM9K5S	Discovery agent	N.A.	Investigative	[1]
Cytidine-5'-Diphosphate	DMA5FGS	Discovery agent	N.A.	Investigative	[1]
Cytidine-5'-Monophosphate	DM6PAXD	Discovery agent	N.A.	Investigative	[2]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.