Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQMXLS)

DTT Name GABA(A) receptor rho2 (GABRR2)
Synonyms Gamma-aminobutyric acid receptor subunit rho-2; GABA(C) receptor2; GABA(A) receptor subunit rho-2
Gene Name GABRR2
DTT Type
Literature-reported target
 [1]
UniProt ID
GBRR2_HUMAN
TTD ID
T90682
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLR
VDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASN
KSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNM
DFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLA
FYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITT
VLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLR
EKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA
RKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS
Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.
KEGG Pathway
Neuroactive ligand-receptor interaction (hsa04080 )
Retrograde endocannabinoid signaling (hsa04723 )
GABAergic synapse (hsa04727 )
Morphine addiction (hsa05032 )
Nicotine addiction (hsa05033 )
Reactome Pathway
GABA receptor activation (R-HSA-977443 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+/-)-cis-2-CAMP DMY3J0B Discovery agent N.A. Investigative [1]
5-Me-IAA DMFZN7J Discovery agent N.A. Investigative [1]
aza-THIP DML70NC Discovery agent N.A. Investigative [1]
cis-3-ACPBPA DMQ0EA7 Discovery agent N.A. Investigative [1]
Isonipecotic acid DMO1ZHE Discovery agent N.A. Investigative [1]
piperidine-4-sulphonic acid DMMIZWE Discovery agent N.A. Investigative [1]
TBPS DMFC3XP Discovery agent N.A. Investigative [1]
TPMPA DMBF6KS Discovery agent N.A. Investigative [1]
trans-3-ACPBPA DM6HI8W Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 9 Investigative Drug(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421).