Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTRFV0W)

DTT Name Bacterial Oxoacyl-[acyl-carrier-protein] synthase II (Bact fabF)
Synonyms
KASB; KAS II; KAS 2; FabF; Condensing enzyme FabF; Beta-ketoacyl-acyl carrier protein synthase B; Beta-ketoacyl-ACP synthase II; Beta-ketoacyl-ACP synthase 2; 3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene Name Bact fabF
DTT Type
Literature-reported target
 [1]
BioChemical Class
Acyltransferase
UniProt ID
FABF_ECOLI
TTD ID
T82723
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 2.3.1.179
Sequence
MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCE
DIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHT
SLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAY
GDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLV
LEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGY
VNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRD
QAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI
Function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.
KEGG Pathway
Fatty acid biosynthesis (ecj00061 )
Biotin metabolism (ecj00780 )
Metabolic pathways (ecj01100 )
Fatty acid metabolism (ecj01212 )
Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway
MetaCyc:3-OXOACYL-ACP-SYNTHII-MON
EcoCyc:3-OXOACYL-ACP-SYNTHII-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lauric Acid DM9C8KQ Discovery agent N.A. Investigative [1]
PLATENSIMYCIN DM9N0RH Bacterial infection 1A00-1C4Z Investigative [2]
Thiolactomycin DMBAWDG Malaria 1F40-1F45 Investigative [3]
------------------------------------------------------------------------------------

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3 Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.