Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTS1W4A)

• DTT Name: Bacterial Deoxyribonucleic acid (Bact DNA)
• Gene Name: Bact DNA
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T49814

Molecular Interaction Atlas (MIA) of This DTT

6 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofazimine	DMEBOFW	Crohn disease	DD70	Approved	[2]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[3]
Hydroxystilbamidine Isethionate	DMR5QS6	Blastomycosis	1F22	Approved	[1]
Metronidazole	DMTIVEN	Abscess		Approved	[4]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[5]
Proflavine	DMF1X5P	Sepsis	1G40-1G41	Approved	[6]

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MGB-BP-3	DMPBTVK	Clostridium infection	1A04	Phase 2	[7]

References

• [1] Interaction between hydroxystilbamidine and DNA. I. Binding isotherms and thermodynamics of the association. Biochim Biophys Acta. 1975 Sep 12;407(1):24-42.
• [2] The mode of action of clofazimine DNA binding studies. Int J Lepr Other Mycobact Dis. 1976 Jan-Jun;44(1-2):133-4.
• [3] Interaction of furazolidone with DNA. Biochim Biophys Acta. 1975 Aug 21;402(2):161-5.
• [4] DNA breakage due to metronidazole treatment. Mutat Res. 2001 Jul 1;478(1-2):153-8.
• [5] On the nature of the adaptive response induced by mitomycin C in Vibrio cholerae OGAWA 154 cells. Biochem Biophys Res Commun. 1996 Mar 27;220(3):509-14.
• [6] Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures. DNA Cell Biol. 2009 Apr;28(4):209-19.
• [7] Clinical pipeline report, company report or official report of MGB Biopharma.