Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTS58YO)

DTT Name	HAO1 messenger RNA (HAO1 mRNA)
Synonyms	HAOX1; Glycolate oxidase; GOX
Gene Name	HAO1
DTT Type	Clinical trial target	[1]
UniProt ID	HAOX1_HUMAN
TTD ID	T43658
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 1.1.3.15
Sequence	MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAET DLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAE AGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQ LRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILR GDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDV LKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLV RKNPLAVSKI
Function	Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
KEGG Pathway	Glyoxylate and dicarboxylate metabolism (hsa00630 ) Metabolic pathways (hsa01100 ) Carbon metabolism (hsa01200 ) Peroxisome (hsa04146 )
Reactome Pathway	Peroxisomal protein import (R-HSA-9033241 ) Glyoxylate metabolism and glycine degradation (R-HSA-389661 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumasiran	DMEBQAO	Hyperoxaluria	5C51.2	Approved	[2]
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References

1	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020