Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSF1KH)

DTT Name Aquaporin-1 (AQP1)
Synonyms Water channel protein for red blood cells and kidney proximal tubule; Urine water channel; CHIP28; Aquaporin-CHIP; AQP-1
Gene Name AQP1
DTT Type
Clinical trial target
 [1]
BioChemical Class
Major intrinsic protein
UniProt ID
AQP1_HUMAN
TTD ID
T44057
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSI
ATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLT
GNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGH
LLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTD
RVKVWTSGQVEEYDLDADDINSRVEMKPK
Function
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
KEGG Pathway
Renin secretion (hsa04924 )
Proximal tubule bicarbonate reclamation (hsa04964 )
Bile secretion (hsa04976 )
Reactome Pathway
Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673 )
Vasopressin regulates renal water homeostasis via Aquaporins (R-HSA-432040 )
Passive transport by Aquaporins (R-HSA-432047 )
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
AAV-AQP1 DMI27RF Xerostomia DA02.1 Phase 1/2 [2]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [1]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 688).
2 Clinical pipeline report, company report or official report of MeiraGTx.