Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSMLOH)

DTT Name Brain-derived neurotrophic factor (BDNF)
Synonyms Brainderived neurotrophic factor; Abrineurin
Gene Name BDNF
DTT Type
Clinical trial target
 [1]
BioChemical Class
Growth factor
UniProt ID
BDNF_HUMAN
TTD ID
T93122
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA
DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA
NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY
FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT
LTIKRGR
Function
Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
cAMP signaling pathway (hsa04024 )
Neurotrophin signaling pathway (hsa04722 )
Huntington's disease (hsa05016 )
Cocaine addiction (hsa05030 )
Alcoholism (hsa05034 )
Reactome Pathway
BDNF activates NTRK2 (TRKB) signaling (R-HSA-9024909 )
Activated NTRK2 signals through RAS (R-HSA-9026519 )
Activated NTRK2 signals through PLCG1 (R-HSA-9026527 )
Activated NTRK2 signals through PI3K (R-HSA-9028335 )
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731 )
Activated NTRK2 signals through FYN (R-HSA-9032500 )
NTRK2 activates RAC1 (R-HSA-9032759 )
Activated NTRK2 signals through CDK5 (R-HSA-9032845 )
MECP2 regulates transcription of neuronal ligands (R-HSA-9022702 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PYM-50028 DMLQK6E Neurological disorder 6B60 Phase 2 [1]
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References

1 PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB J. 2008 Jul;22(7):2488-97.