Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTU8W4S)

• DTT Name: Protein kinase (PK)
• Gene Name: PK
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Kinase
• UniProt ID: NOUNIPROTAC
• TTD ID: T78874

Molecular Interaction Atlas (MIA) of This DTT

7 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MGCD516	DM752PU	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[2]
ENMD-2076	DMJZVPB	Acute myeloid leukaemia	2A60	Phase 2	[2]
LY2801653	DM0KJDY	Biliary tract cancer	2C17	Phase 2	[2]
MGCD265	DMRPCF2	Non-small-cell lung cancer	2C25.Y	Phase 2	[2]
RV-568	DM652CM	Asthma	CA23	Phase 2	[1]
LX-7101	DM2LYIN	Glaucoma/ocular hypertension	9C61	Phase 1/2	[3]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[4]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclocreatine	DM1I7UO	Virus infection	1A24-1D9Z	Discontinued in Phase 1	[5]

References

• [1] Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Design, synthesis and biological characterization of selective LIMK inhibitors. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4005-10.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Direct determination of creatine kinase equilibrium constants with creatine or cyclocreatine substrate. Biochim Biophys Acta. 1989 Oct 19;998(3):317-20.