General Information of Drug Therapeutic Target (DTT) (ID: TTULV0X)

DTT Name Reactive oxygen species (ROS)
Gene Name ROS
DTT Type
Successful target
[1]
UniProt ID
NOUNIPROTAC
TTD ID
T20796

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tafenoquine DM1XT4N Malaria 1F40-1F45 Approved [1]
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3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoquinone DMKPZ0Q Hepatitis C virus infection 1E51.1 Phase 2 [2]
Procysteine DMF9RB4 Amyotrophic lateral sclerosis 8B60.0 Phase 2 [3]
Sodium pyruvate DMST6A3 Asthma CA23 Phase 1/2 [4]
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References

1 Tafenoquine: First Global Approval.Drugs. 2018 Sep;78(14):1517-1523.
2 Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels. Int J Mol Sci. 2020 Aug 27;21(17):6192.
3 Protective effect of procysteine on Acinetobacter pneumonia in hyperoxic conditions. J Antimicrob Chemother. 2013 Oct;68(10):2305-10.
4 A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol. 2006 Sep;70(3):925-35.