Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTUSC27)

DTT Name	Solute carrier family 38 member 2 (SLC38A2)
Synonyms	System N amino acid transporter 2; System A transporter 1; System A amino acid transporter 2; Sodium-coupled neutral amino acid transporter 2; SNAT2; SAT2; Protein 40-9-1; KIAA1382; Amino acid transporter A2; ATA2
Gene Name	SLC38A2
DTT Type	Literature-reported target	[1]
UniProt ID	S38A2_HUMAN
TTD ID	T96273
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKK KYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVH LLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQAL TNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKK FQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILI FSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLH TYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSI LAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLL SGVLVMTGSMALIVLDWVHNAPGGGH
Function	Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
KEGG Pathway	Glutamatergic synapse (hsa04724 ) GABAergic synapse (hsa04727 ) Protein digestion and absorption (hsa04974 )
Reactome Pathway	Amino acid transport across the plasma membrane (R-HSA-352230 ) Glutamate Neurotransmitter Release Cycle (R-HSA-210500 )

The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Sodium-coupled neutral amino acid transporter 2 (SLC38A2) DTP Info

Gene Name

SLC38A2

2 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[2]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1170).
2	Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.