Details of the Drug

General Information of Drug (ID: DM69G8X)

Drug Name
L-glutamine
Synonyms
NutreStore; AES-14; Aesgen-14; Glutamine (INN); L-glutamine (oral, short bowel syndrome), Emmaus; L-glutamine (topical, chemotherapy-induced mucositis), Aesgen; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus/University of California Los Angeles
Indication
Disease Entry ICD 11 Status REF
Short bowel syndrome KB89.1 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 146.14
Logarithm of the Partition Coefficient (xlogp) -3.1
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 30 min []
Half-life
The concentration or amount of drug in body reduced by one-half in 1 hour []
Vd
The volume of distribution (Vd) of drug is 0.2 L/kg []
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Apoptosis Not Available LTBP1 OTR7Q75L [2]
Cytogenetic investigations Not Available GFPT1 OTQBDO45 [2]
Cytogenetic investigations Not Available EGFR OTAPLO1S [2]
Gastrointestinal disorders Not Available CNX1 OTLOSIX2 [2]
Chemical Identifiers
Formula
C5H10N2O3
IUPAC Name
(2S)-2,5-diamino-5-oxopentanoic acid
Canonical SMILES
C(CC(=O)N)[C@@H](C(=O)O)N
InChI
InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKey
ZDXPYRJPNDTMRX-VKHMYHEASA-N
Cross-matching ID
PubChem CID
5961
ChEBI ID
CHEBI:18050
CAS Number
56-85-9
DrugBank ID
DB00130
TTD ID
D01JIA
VARIDT ID
DR00024

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DTKWJH3 S38A3_HUMAN Substrate [3]
Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7) DT2EGUN S38A7_HUMAN Substrate [3]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5) DTLX28N S38A5_HUMAN Substrate [3]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4) DTPJBD5 S38A4_HUMAN Substrate [3]
Sodium-coupled neutral amino acid transporter 2 (SLC38A2) DTTWL58 S38A2_HUMAN Substrate [3]
Sodium-coupled neutral amino acid transporter 1 (SLC38A1) DTD815L S38A1_HUMAN Substrate [3]
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTW7AE3 AAAT_HUMAN Substrate [4]
L-type amino acid transporter 1 (SLC7A5) DT48T0N LAT1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Calnexin homolog 1 (CNX1) OTLOSIX2 CALX1_ARATH Drug Response [2]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Drug Response [2]
Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1) OTQBDO45 GFPT1_HUMAN Drug Response [2]
Latent-transforming growth factor beta-binding protein 1 (LTBP1) OTR7Q75L LTBP1_HUMAN Drug Response [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 723).
2 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
3 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.
4 High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5.
5 Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34.