Details of the Drug

General Information of Drug (ID: DMFW5VK)

• Drug Name: ISIS 100748

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Antisense drug
• Sequence: AGCAATTCCCATAAGTAATA
• Cross-matching ID: TTD ID: D02CNG

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ADAM10 messenger RNA (ADAM10 mRNA)	TTVXEGU	ADA10_HUMAN	Not Available	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ADAM10 messenger RNA (ADAM10 mRNA)	DTT	ADAM10	9.12E-20	0.59	0.82

References

• [1] US patent application no. 6,228,648, Antisense modulation of ADAM10 expression.