Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWU04I)

DTT Name	HUMAN prostaglandin E synthase 2 (PTGES2)
Synonyms	Prostaglandin-H(2) E-isomerase; mPGES-2; mPGE synthase-2 ; Microsomal prostaglandin E synthase 2; Membrane-associated prostaglandin E synthase-2
Gene Name	PTGES2
BioChemical Class	GST superfamily
UniProt ID	PGES2_HUMAN
TTD ID	T01037
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 5.3.99.3
Sequence	MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLG AAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFL DFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADD WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQ DNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQ PWYLRVERAITEASPAH
Function	Human protein prostaglandin E synthase 2 interacts with SARS-CoV-2 Nsp7 protein with high significance, which indicates PTGES2 as a potential therapeutic target.
KEGG Pathway	Arachidonic acid metabolism (hsa00590 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Neutrophil degranulation (R-HSA-6798695 ) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (R-HSA-2162123 )
BioCyc Pathway	MetaCyc:HS07514-MON

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Prostaglandin E synthase 2 (PTGES2) DME Info

Gene Name

PTGES2

1 Clinical Trial Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[2]
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References

1	A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.
2	Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem. 2003 Jun 20;278(25):22199-209.