Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZ3IFB)

• DTT Name: Phosphogluconate dehydrogenase (PGD) DTT Info
• Gene Name: PGD

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GHRP-2	DMKGH0R	Growth hormone deficiency	5A61.3	Approved	[1]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2R)-2-Methyl-4,5-dideoxy	DM3K2TI	Discovery agent	N.A.	Investigative	[1]
4-phospho-D-erythronate	DMW4KXQ	Discovery agent	N.A.	Investigative	[2]
5-deoxy-5-phosphono-D-arabinonate	DM65XZJ	Discovery agent	N.A.	Investigative	[3]
6-Phosphogluconic Acid	DMB1QCY	Discovery agent	N.A.	Investigative	[4]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[5]

References

• [1] Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14.
• [2] Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62.
• [3] Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.