Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZFUY6)

DTT Name	Serine Racemase (SRR)
Synonyms	L-serine dehydratase; L-serine ammonia-lyase; D-serine dehydratase; D-serine ammonia-lyase
Gene Name	SRR
DTT Type	Literature-reported target	[1]
BioChemical Class	Racemases and epimerase
UniProt ID	SRR_HUMAN
TTD ID	T00477
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 5.1.1.18
Sequence	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
Function	D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. Catalyzes the synthesis of D-serine from L-serine.
KEGG Pathway	Glycine, serine and threonine metabolism (hsa00260 ) D-Amino acid metabolism (hsa00470 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Serine biosynthesis (R-HSA-977347 )
BioCyc Pathway	MetaCyc:HS09614-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-erythro-3-hydroxyaspartate	DMV4OKR	Neurodegenerative disorder	8A20-8A23	Investigative	[1]
Malonic acid	DMM5QXL	Neurodegenerative disorder	8A20-8A23	Investigative	[1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Serine racemase (SRR) DME Info

Gene Name

SRR

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[2]
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References

1	Inhibition of human serine racemase, an emerging target for medicinal chemistry. Curr Drug Targets. 2011 Jun;12(7):1037-55.
2	D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.