Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZJD1B)

DTT Name Acetylcholine release (Ach rele)
Gene Name Ach rele
DTT Type
Successful target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T03006

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Abobotulinum toxin A DMZT2P0 Cervical cancer 2C77.0 Approved [2]
Incobotulinum toxin A DMKE6YT Cervical cancer 2C77.0 Approved [1]
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2 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
HOE-065 DMNC1A3 Cognitive impairment 6D71 Discontinued in Phase 1 [3]
KW-6055 DM76O23 Inflammation 1A00-CA43.1 Discontinued in Phase 1 [4]
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References

1 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
2 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
3 Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents. Eur J Pharmacol. 1989 Nov 14;171(1):79-85.
4 Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43.