Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE3PZ0I)

• DME Name: Histamine N-methyltransferase (HNMT) DME Info
• Gene Name: HNMT

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	6.30E-01	-8.33E-02	-4.35E-01
Alopecia	ED70	Skin from scalp	1.60E-07	4.12E-01	1.21E+00
Alzheimer's disease	8A20	Entorhinal cortex	9.15E-03	6.93E-02	3.56E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.92E-01	1.01E-01	2.51E-01
Aortic stenosis	BB70	Calcified aortic valve	4.94E-01	5.78E-02	3.99E-01
Apnea	7A40	Hyperplastic tonsil	1.09E-01	1.33E-01	6.03E-01
Arthropathy	FA00-FA5Z	Peripheral blood	3.97E-01	1.50E-01	5.67E-01
Asthma	CA23	Nasal and bronchial airway	1.46E-03	-2.77E-01	-3.05E-01
Atopic dermatitis	EA80	Skin	8.15E-02	-1.12E-01	-5.47E-01
Autism	6A02	Whole blood	8.48E-01	-5.95E-02	-2.73E-01
Autoimmune uveitis	9A96	Peripheral monocyte	1.16E-01	-2.63E-01	-6.71E-01
Autosomal dominant monocytopenia	4B04	Whole blood	5.89E-04	-2.51E-01	-1.35E+00
Bacterial infection of gingival	1C1H	Gingival tissue	1.87E-01	4.64E-02	1.72E-01
Batten disease	5C56.1	Whole blood	4.69E-01	7.50E-02	2.14E-01
Behcet's disease	4A62	Peripheral blood	1.12E-01	1.92E-01	5.67E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.39E-01	-1.85E-02	-9.88E-02
Bladder cancer	2C94	Bladder tissue	1.53E-04	-9.39E-01	-2.79E+00
Breast cancer	2C60-2C6Z	Breast tissue	5.38E-66	-4.62E-01	-1.37E+00
Cardioembolic stroke	8B11.20	Whole blood	4.08E-04	4.88E-01	1.18E+00
Cervical cancer	2C77	Cervical tissue	4.51E-01	-1.45E-01	-3.22E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	4.82E-01	-5.17E-02	-1.30E-01
Chronic hepatitis C	1E51.1	Whole blood	5.43E-01	-9.53E-02	-1.85E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	3.08E-01	-1.38E-03	-6.26E-03
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	8.20E-04	-1.66E-01	-4.37E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	2.64E-01	-1.00E-01	-2.33E-01
Colon cancer	2B90	Colon tissue	2.48E-09	-1.74E-01	-5.05E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	4.21E-01	-1.84E-01	-8.08E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	2.11E-01	-1.78E-01	-1.11E+00
Endometriosis	GA10	Endometrium tissue	5.11E-03	4.32E-01	1.42E+00
Familial hypercholesterolemia	5C80.00	Peripheral blood	1.28E-01	-1.72E-01	-7.70E-01
Familial hypercholesterolemia	5C80.00	Whole blood	6.48E-10	1.16E+00	2.06E+00
Gastric cancer	2B72	Gastric tissue	1.25E-01	4.02E-01	1.45E+00
Glioblastopma	2A00.00	Nervous tissue	5.18E-62	4.45E-01	2.04E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	7.68E-01	-1.86E-01	-5.55E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	3.69E-01	3.64E-01	3.67E-01
Head and neck cancer	2D42	Head and neck tissue	1.31E-13	-3.34E-01	-8.91E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	4.70E-02	2.79E-01	1.01E+00
Huntington's disease	8A01.10	Whole blood	6.72E-01	-4.03E-03	-2.17E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	6.90E-02	6.38E-01	1.24E+00
Immunodeficiency	4A00-4A20	Peripheral blood	7.15E-01	2.28E-02	2.31E-01
Influenza	1E30	Whole blood	2.68E-01	-1.27E+00	-1.29E+00
Interstitial cystitis	GC00.3	Bladder tissue	9.82E-03	-6.54E-01	-3.58E+00
Intracranial aneurysm	8B01.0	Intracranial artery	1.82E-01	1.35E-01	6.64E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	3.14E-03	-1.65E-01	-5.46E-01
Ischemic stroke	8B11	Peripheral blood	1.27E-01	-5.68E-02	-1.34E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	4.54E-02	9.80E-03	1.22E-02
Lateral sclerosis	8B60.4	Skin	1.30E-01	2.34E-01	1.14E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	2.32E-03	1.43E-01	2.75E+00
Liver cancer	2C12.0	Liver tissue	2.26E-03	-5.27E-01	-7.73E-01
Liver failure	DB99.7-DB99.8	Liver tissue	7.46E-05	4.80E-01	2.62E+00
Lung cancer	2C25	Lung tissue	1.17E-47	-5.59E-01	-1.35E+00
Lupus erythematosus	4A40	Whole blood	2.42E-03	3.69E-01	3.20E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	4.96E-01	-3.52E-02	-2.03E-01
Major depressive disorder	6A70-6A7Z	Whole blood	2.23E-01	1.25E-01	3.37E-01
Melanoma	2C30	Skin	7.78E-01	-2.53E-02	-3.27E-02
Multiple myeloma	2A83.1	Peripheral blood	1.16E-01	2.22E-02	1.82E-01
Multiple myeloma	2A83.1	Bone marrow	1.55E-01	-2.28E-01	-4.83E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.83E-01	1.62E-02	7.03E-02
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	1.09E-05	3.30E-01	1.11E+00
Myelofibrosis	2A20.2	Whole blood	4.79E-01	1.42E-01	7.73E-01
Myocardial infarction	BA41-BA50	Peripheral blood	2.59E-06	6.14E-01	9.11E-01
Myopathy	8C70.6	Muscle tissue	1.57E-06	5.24E-01	4.64E+00
Neonatal sepsis	KA60	Whole blood	1.79E-12	2.37E-01	1.01E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	3.85E-06	-5.08E-01	-2.61E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	7.95E-01	-6.76E-03	-3.84E-02
Obesity related type 2 diabetes	5A11	Omental adipose tissue	1.75E-01	-1.25E-01	-1.41E+00
Olive pollen allergy	CA08.00	Peripheral blood	3.28E-01	-9.15E-02	-7.49E-01
Oral cancer	2B6E	Oral tissue	4.01E-02	-1.45E-01	-3.95E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	8.47E-01	-4.99E-03	-1.76E-02
Osteoporosis	FB83.1	Bone marrow	3.58E-01	-5.28E-01	-8.69E-01
Ovarian cancer	2C73	Ovarian tissue	7.74E-04	-8.60E-01	-1.86E+00
Pancreatic cancer	2C10	Pancreas	1.67E-02	2.89E-01	7.00E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	6.70E-01	1.08E-01	5.85E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	5.19E-03	4.03E-01	1.28E+00
Pituitary cancer	2D12	Pituitary tissue	9.24E-01	6.52E-02	2.22E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	6.79E-01	-8.42E-02	-4.51E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.97E-01	-3.46E-02	-4.09E-01
Polycythemia vera	2A20.4	Whole blood	9.86E-02	1.07E-01	6.25E-01
Pompe disease	5C51.3	Biceps muscle	1.26E-02	4.55E-01	9.90E-01
Preterm birth	KA21.4Z	Myometrium	9.50E-01	8.15E-02	4.35E-01
Prostate cancer	2C82	Prostate	1.00E-04	2.09E+00	1.88E+00
Psoriasis	EA90	Skin	2.71E-01	3.57E-02	9.43E-02
Rectal cancer	2B92	Rectal colon tissue	3.18E-02	-4.19E-01	-1.43E+00
Renal cancer	2C90-2C91	Kidney	4.28E-03	4.33E-01	1.59E+00
Retinoblastoma	2D02.2	Uvea	1.92E-04	6.99E-01	5.82E+00
Rheumatoid arthritis	FA20	Synovial tissue	1.14E-01	1.57E-01	2.78E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	9.97E-01	1.43E-02	8.11E-02
Schizophrenia	6A20	Prefrontal cortex	6.81E-02	5.72E-02	1.46E-01
Schizophrenia	6A20	Superior temporal cortex	9.33E-01	-1.67E-02	-9.76E-02
Scleroderma	4A42.Z	Whole blood	2.65E-02	9.00E-02	4.47E-01
Seizure	8A60-8A6Z	Whole blood	6.35E-01	-9.15E-02	-4.53E-01
Sensitive skin	EK0Z	Skin	3.54E-01	-1.87E-01	-1.49E+00
Sepsis with septic shock	1G41	Whole blood	2.36E-07	9.81E-02	4.14E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	5.58E-01	-1.57E-01	-5.44E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.05E-01	-1.19E-01	-1.02E+00
Simpson golabi behmel syndrome	LD2C	Adipose tissue	7.28E-01	3.01E-02	5.42E-02
Sjogren's syndrome	4A43.2	Salivary gland tissue	1.25E-02	5.32E-01	3.71E+00
Skin cancer	2C30-2C3Z	Skin	2.23E-01	7.77E-04	1.41E-03
Thrombocythemia	3B63	Whole blood	8.96E-01	3.64E-03	1.99E-02
Thrombocytopenia	3B64	Whole blood	2.57E-01	3.66E-01	9.69E-01
Thyroid cancer	2D10	Thyroid	1.98E-01	4.51E-02	1.51E-01
Tibial muscular dystrophy	8C75	Muscle tissue	4.12E-06	9.31E-01	2.39E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	2.49E-02	4.33E-01	1.03E+01
Type 2 diabetes	5A11	Liver tissue	6.33E-01	-1.71E-01	-3.37E-01
Ureter cancer	2C92	Urothelium	3.13E-01	-9.15E-02	-4.91E-01
Uterine cancer	2C78	Endometrium tissue	5.54E-20	-5.81E-01	-1.25E+00
Vitiligo	ED63.0	Skin	9.07E-01	-1.04E-01	-3.27E-01