Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE6BOK3)

• DME Name: Beta,beta-carotene 15,15'-dioxygenase (BCO1) DME Info
• Gene Name: BCO1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.04E-02	2.96E-02	1.79E-01
Alopecia	ED70	Skin from scalp	7.39E-01	-4.72E-02	-1.16E-01
Alzheimer's disease	8A20	Entorhinal cortex	1.00E+00	1.01E-02	3.72E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	8.09E-01	1.75E-02	1.87E-01
Aortic stenosis	BB70	Calcified aortic valve	7.39E-01	6.15E-02	9.41E-02
Apnea	7A40	Hyperplastic tonsil	1.76E-02	-8.39E-01	-7.82E-01
Arthropathy	FA00-FA5Z	Peripheral blood	2.55E-02	1.13E-01	8.72E-01
Asthma	CA23	Nasal and bronchial airway	9.50E-06	1.25E+00	9.09E-01
Atopic dermatitis	EA80	Skin	5.15E-02	-9.73E-02	-3.24E-01
Autism	6A02	Whole blood	4.60E-01	4.17E-02	2.37E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.11E-01	1.38E-01	7.83E-01
Autosomal dominant monocytopenia	4B04	Whole blood	3.70E-01	6.09E-02	3.28E-01
Bacterial infection of gingival	1C1H	Gingival tissue	1.03E-10	-5.27E-01	-9.85E-01
Batten disease	5C56.1	Whole blood	2.80E-01	9.21E-02	8.03E-01
Behcet's disease	4A62	Peripheral blood	9.34E-01	-4.39E-02	-2.92E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.35E-01	-6.53E-03	-4.10E-02
Bladder cancer	2C94	Bladder tissue	2.03E-03	2.13E-01	1.29E+00
Breast cancer	2C60-2C6Z	Breast tissue	6.55E-04	-8.79E-02	-3.46E-01
Cardioembolic stroke	8B11.20	Whole blood	7.15E-02	1.05E-01	6.28E-01
Cervical cancer	2C77	Cervical tissue	1.15E-02	-3.59E-01	-8.71E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	9.86E-01	5.66E-02	2.22E-01
Chronic hepatitis C	1E51.1	Whole blood	9.20E-01	-1.54E-03	-6.38E-03
Chronic obstructive pulmonary disease	CA22	Lung tissue	1.35E-01	7.84E-02	4.82E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	6.89E-01	-1.89E-02	-7.06E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	2.27E-02	1.34E-01	1.16E+00
Colon cancer	2B90	Colon tissue	2.28E-21	-5.46E-01	-1.04E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	6.41E-01	-6.98E-02	-4.10E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	6.61E-01	-5.97E-02	-3.47E-01
Endometriosis	GA10	Endometrium tissue	1.09E-03	1.37E-01	3.93E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	9.81E-01	3.85E-02	4.50E-01
Familial hypercholesterolemia	5C80.00	Whole blood	9.07E-01	-5.45E-02	-3.48E-01
Gastric cancer	2B72	Gastric tissue	3.07E-01	4.60E-01	5.88E-01
Glioblastopma	2A00.00	Nervous tissue	1.18E-42	2.70E-01	8.63E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	3.44E-01	6.81E-02	5.18E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	1.25E-01	-1.83E-01	-5.71E-01
Head and neck cancer	2D42	Head and neck tissue	2.81E-04	-2.36E-01	-7.97E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	1.14E-01	4.63E-02	5.74E-01
Huntington's disease	8A01.10	Whole blood	7.84E-01	-7.53E-03	-5.72E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	6.64E-01	2.03E-02	1.95E-01
Immunodeficiency	4A00-4A20	Peripheral blood	4.29E-01	6.05E-02	5.20E-01
Influenza	1E30	Whole blood	8.79E-01	-3.96E-02	-3.60E-01
Interstitial cystitis	GC00.3	Bladder tissue	4.77E-01	-9.54E-02	-9.37E-01
Intracranial aneurysm	8B01.0	Intracranial artery	3.09E-01	-5.42E-02	-3.26E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	5.05E-01	2.52E-02	4.63E-02
Ischemic stroke	8B11	Peripheral blood	3.23E-01	1.11E-02	6.71E-02
Juvenile idiopathic arthritis	FA24	Peripheral blood	3.54E-02	5.93E-02	2.32E-01
Lateral sclerosis	8B60.4	Skin	1.31E-02	1.08E-01	2.34E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	5.19E-01	-1.71E-02	-4.35E-02
Liver cancer	2C12.0	Liver tissue	9.37E-01	-8.53E-02	-3.01E-01
Liver failure	DB99.7-DB99.8	Liver tissue	1.10E-01	-1.00E-01	-4.70E-01
Lung cancer	2C25	Lung tissue	1.24E-74	2.66E-01	1.47E+00
Lupus erythematosus	4A40	Whole blood	9.26E-01	-4.18E-02	-1.37E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	8.89E-01	-1.04E-02	-6.17E-02
Major depressive disorder	6A70-6A7Z	Whole blood	2.17E-01	7.89E-02	2.51E-01
Melanoma	2C30	Skin	2.71E-01	-8.39E-02	-1.58E-01
Multiple myeloma	2A83.1	Peripheral blood	3.55E-01	1.26E-01	9.05E-01
Multiple myeloma	2A83.1	Bone marrow	1.40E-01	-1.44E-01	-9.70E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	5.43E-02	1.96E-01	1.21E+00
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	9.51E-04	7.39E-02	4.55E-01
Myelofibrosis	2A20.2	Whole blood	2.22E-02	-5.33E-02	-3.89E-01
Myocardial infarction	BA41-BA50	Peripheral blood	7.96E-01	3.86E-02	5.43E-02
Myopathy	8C70.6	Muscle tissue	5.42E-01	-5.56E-02	-2.24E-01
Neonatal sepsis	KA60	Whole blood	5.07E-01	2.08E-02	1.27E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.59E-01	-1.63E-01	-7.72E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	9.78E-01	-1.02E-01	-5.84E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	2.27E-01	1.24E-01	7.96E-01
Olive pollen allergy	CA08.00	Peripheral blood	2.29E-02	1.85E-01	1.81E+00
Oral cancer	2B6E	Oral tissue	8.18E-02	-1.36E-01	-1.47E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.50E-01	4.68E-02	2.44E-01
Osteoporosis	FB83.1	Bone marrow	4.21E-02	1.58E-01	9.75E-01
Ovarian cancer	2C73	Ovarian tissue	1.04E-01	-1.63E-01	-5.91E-01
Pancreatic cancer	2C10	Pancreas	6.36E-09	6.06E-01	2.06E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	6.45E-01	5.75E-03	2.48E-02
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	2.79E-01	1.64E-02	1.38E-01
Pituitary cancer	2D12	Pituitary tissue	1.58E-01	1.51E-01	2.66E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	2.49E-02	6.49E-01	1.13E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.66E-01	-7.21E-03	-7.24E-02
Polycythemia vera	2A20.4	Whole blood	1.08E-01	-5.40E-02	-3.74E-01
Pompe disease	5C51.3	Biceps muscle	1.91E-01	-3.95E-02	-2.35E-01
Preterm birth	KA21.4Z	Myometrium	4.60E-01	-2.15E-02	-1.39E-01
Prostate cancer	2C82	Prostate	5.67E-01	7.23E-02	9.49E-02
Psoriasis	EA90	Skin	3.29E-11	-2.38E-01	-7.16E-01
Rectal cancer	2B92	Rectal colon tissue	3.63E-03	-9.94E-01	-1.87E+00
Renal cancer	2C90-2C91	Kidney	3.97E-06	7.27E-01	2.15E+00
Retinoblastoma	2D02.2	Uvea	2.14E-01	1.02E-01	1.02E+00
Rheumatoid arthritis	FA20	Synovial tissue	4.35E-01	-9.36E-02	-4.77E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	5.04E-03	-1.78E-01	-5.29E-01
Schizophrenia	6A20	Prefrontal cortex	5.76E-01	-1.54E-02	-6.56E-02
Schizophrenia	6A20	Superior temporal cortex	4.60E-01	4.91E-03	4.75E-02
Scleroderma	4A42.Z	Whole blood	9.70E-04	3.79E-01	1.90E+00
Seizure	8A60-8A6Z	Whole blood	9.75E-01	-1.02E-02	-5.48E-02
Sensitive skin	EK0Z	Skin	7.25E-01	0.00E+00	0.00E+00
Sepsis with septic shock	1G41	Whole blood	8.45E-11	1.36E-01	6.76E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	4.86E-01	1.28E-01	6.10E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	8.69E-01	1.18E-01	8.07E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	1.32E-01	1.99E-01	1.65E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.50E-01	7.87E-02	7.38E-01
Skin cancer	2C30-2C3Z	Skin	1.98E-14	-2.93E-01	-8.72E-01
Thrombocythemia	3B63	Whole blood	1.14E-01	-6.71E-02	-4.83E-01
Thrombocytopenia	3B64	Whole blood	4.42E-01	2.14E-01	1.04E+00
Thyroid cancer	2D10	Thyroid	4.15E-02	4.78E-02	2.38E-01
Tibial muscular dystrophy	8C75	Muscle tissue	5.86E-01	-2.22E-02	-1.45E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.70E-02	2.04E-01	1.96E+00
Type 2 diabetes	5A11	Liver tissue	8.64E-01	1.24E-02	9.05E-02
Ureter cancer	2C92	Urothelium	9.68E-02	-1.24E-01	-5.69E-01
Uterine cancer	2C78	Endometrium tissue	4.83E-01	-9.32E-02	-1.28E-01
Vitiligo	ED63.0	Skin	6.85E-01	-1.26E-01	-4.13E-01