Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE915QP)

• DME Name: Ketoacyl-CoA reductase (HSD17B12) DME Info
• Gene Name: HSD17B12

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	8.84E-02	-4.50E-02	-1.71E-01
Alopecia	ED70	Skin from scalp	4.42E-02	9.33E-02	1.97E-01
Alzheimer's disease	8A20	Entorhinal cortex	8.63E-05	-6.97E-02	-2.02E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	1.37E-01	-2.64E-01	-8.42E-01
Aortic stenosis	BB70	Calcified aortic valve	8.07E-01	-7.93E-02	-1.05E-01
Apnea	7A40	Hyperplastic tonsil	5.60E-01	-1.01E-01	-4.71E-01
Arthropathy	FA00-FA5Z	Peripheral blood	2.87E-01	3.42E-02	3.69E-01
Asthma	CA23	Nasal and bronchial airway	1.58E-02	-1.18E-01	-1.66E-01
Atopic dermatitis	EA80	Skin	5.23E-01	-1.39E-01	-5.10E-01
Autism	6A02	Whole blood	2.24E-01	-3.71E-02	-3.26E-01
Autoimmune uveitis	9A96	Peripheral monocyte	9.59E-01	1.12E-01	5.84E-01
Autosomal dominant monocytopenia	4B04	Whole blood	9.30E-01	-9.90E-02	-3.60E-01
Bacterial infection of gingival	1C1H	Gingival tissue	3.67E-02	-6.25E-02	-3.36E-01
Batten disease	5C56.1	Whole blood	7.22E-01	7.79E-03	2.86E-02
Behcet's disease	4A62	Peripheral blood	8.97E-01	-4.26E-02	-2.40E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	2.75E-02	-1.32E-01	-7.46E-01
Bladder cancer	2C94	Bladder tissue	1.60E-02	3.10E-01	1.06E+00
Breast cancer	2C60-2C6Z	Breast tissue	4.50E-07	4.74E-02	2.41E-01
Cardioembolic stroke	8B11.20	Whole blood	1.84E-01	1.76E-02	4.39E-02
Cervical cancer	2C77	Cervical tissue	9.86E-01	-2.06E-02	-1.16E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	1.54E-02	-8.75E-02	-7.66E-01
Chronic hepatitis C	1E51.1	Whole blood	3.72E-02	2.27E-01	8.63E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	6.20E-02	9.17E-02	6.08E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	5.78E-01	-4.55E-03	-1.66E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	6.18E-01	-2.61E-02	-2.09E-01
Colon cancer	2B90	Colon tissue	6.51E-47	3.04E-01	1.32E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	3.26E-02	-2.19E-01	-1.58E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	4.00E-01	2.52E-01	4.92E-01
Endometriosis	GA10	Endometrium tissue	7.90E-01	2.33E-03	1.01E-02
Familial hypercholesterolemia	5C80.00	Peripheral blood	8.05E-02	-1.38E-02	-1.05E-01
Familial hypercholesterolemia	5C80.00	Whole blood	8.73E-04	-1.88E-01	-1.06E+00
Gastric cancer	2B72	Gastric tissue	2.34E-02	2.75E-01	2.74E+00
Glioblastopma	2A00.00	Nervous tissue	6.17E-01	-3.35E-03	-1.19E-02
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	8.71E-01	-3.15E-03	-3.83E-02
Glioma	2A00.0Y-2A00.0Z	White matter tissue	8.78E-01	2.44E-01	2.71E-01
Head and neck cancer	2D42	Head and neck tissue	6.35E-06	-1.22E-01	-6.04E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	8.98E-01	-4.25E-02	-3.77E-01
Huntington's disease	8A01.10	Whole blood	2.77E-01	-1.29E-02	-1.25E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	3.67E-01	1.75E-02	5.01E-02
Immunodeficiency	4A00-4A20	Peripheral blood	2.32E-01	3.43E-02	1.86E-01
Influenza	1E30	Whole blood	1.70E-01	4.16E-01	1.36E+00
Interstitial cystitis	GC00.3	Bladder tissue	8.47E-01	-1.76E-03	-9.40E-03
Intracranial aneurysm	8B01.0	Intracranial artery	4.97E-03	-2.12E-01	-1.18E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	1.05E-01	1.28E-01	3.13E-01
Ischemic stroke	8B11	Peripheral blood	9.99E-01	-2.87E-02	-2.41E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	4.41E-02	1.46E-01	3.12E-01
Lateral sclerosis	8B60.4	Skin	1.62E-01	1.42E-01	1.36E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	9.66E-01	1.73E-02	6.18E-02
Liver cancer	2C12.0	Liver tissue	1.19E-01	-9.99E-02	-3.10E-01
Liver failure	DB99.7-DB99.8	Liver tissue	2.09E-01	-2.14E-01	-6.57E-01
Lung cancer	2C25	Lung tissue	9.88E-14	1.33E-01	5.55E-01
Lupus erythematosus	4A40	Whole blood	1.75E-01	1.32E-02	5.04E-02
Major depressive disorder	6A70-6A7Z	Hippocampus	8.19E-02	-1.13E-01	-6.19E-01
Major depressive disorder	6A70-6A7Z	Whole blood	5.73E-01	1.98E-02	7.97E-02
Melanoma	2C30	Skin	1.83E-01	-3.48E-01	-3.71E-01
Multiple myeloma	2A83.1	Peripheral blood	7.61E-01	7.97E-02	4.16E-01
Multiple myeloma	2A83.1	Bone marrow	5.13E-01	-7.68E-02	-4.02E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	7.76E-01	-1.30E-01	-2.17E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	5.33E-01	6.72E-02	1.90E-01
Myelofibrosis	2A20.2	Whole blood	6.81E-04	2.17E-01	1.44E+00
Myocardial infarction	BA41-BA50	Peripheral blood	6.34E-02	-4.30E-01	-4.49E-01
Myopathy	8C70.6	Muscle tissue	6.38E-01	1.76E-02	1.40E-01
Neonatal sepsis	KA60	Whole blood	2.41E-01	1.31E-02	9.73E-02
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.45E-03	1.90E-01	1.22E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	8.58E-01	1.84E-02	1.34E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	5.56E-01	-2.87E-02	-8.87E-02
Olive pollen allergy	CA08.00	Peripheral blood	1.51E-01	1.62E-01	1.40E+00
Oral cancer	2B6E	Oral tissue	4.32E-01	3.81E-02	1.59E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	6.30E-01	-3.90E-02	-1.48E-01
Osteoporosis	FB83.1	Bone marrow	5.09E-01	7.08E-02	3.91E-01
Ovarian cancer	2C73	Ovarian tissue	9.75E-02	1.74E-02	1.48E-01
Pancreatic cancer	2C10	Pancreas	5.98E-03	-3.90E-01	-1.01E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	1.18E-01	-8.23E-02	-4.95E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	2.14E-01	-3.88E-02	-2.81E-01
Pituitary cancer	2D12	Pituitary tissue	1.32E-01	2.24E-01	6.57E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	2.41E-01	1.99E-01	6.05E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	8.23E-01	-2.25E-03	-2.36E-02
Polycythemia vera	2A20.4	Whole blood	1.06E-03	6.84E-02	4.41E-01
Pompe disease	5C51.3	Biceps muscle	8.28E-01	1.71E-02	6.52E-02
Preterm birth	KA21.4Z	Myometrium	3.95E-01	-5.56E-02	-3.52E-01
Prostate cancer	2C82	Prostate	1.23E-07	1.18E+00	2.20E+00
Psoriasis	EA90	Skin	6.75E-11	2.52E-01	8.02E-01
Rectal cancer	2B92	Rectal colon tissue	6.84E-01	-1.12E-01	-5.40E-01
Renal cancer	2C90-2C91	Kidney	5.04E-02	1.21E-01	7.45E-01
Retinoblastoma	2D02.2	Uvea	5.46E-01	1.77E-01	6.58E-01
Rheumatoid arthritis	FA20	Synovial tissue	4.61E-02	-5.69E-01	-1.37E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	4.98E-01	-1.10E-02	-9.23E-02
Schizophrenia	6A20	Prefrontal cortex	2.03E-01	-5.76E-02	-2.97E-01
Schizophrenia	6A20	Superior temporal cortex	3.22E-01	3.57E-02	3.70E-01
Scleroderma	4A42.Z	Whole blood	3.98E-04	1.83E-01	1.64E+00
Seizure	8A60-8A6Z	Whole blood	8.04E-01	-3.23E-02	-2.45E-01
Sensitive skin	EK0Z	Skin	3.37E-01	-1.66E-01	-5.86E-01
Sepsis with septic shock	1G41	Whole blood	3.79E-03	4.53E-02	2.80E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	1.91E-01	2.33E-01	3.76E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	6.83E-02	5.33E-02	5.03E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	9.69E-01	-2.65E-02	-4.30E-02
Sjogren's syndrome	4A43.2	Salivary gland tissue	9.40E-01	6.82E-02	3.18E-01
Skin cancer	2C30-2C3Z	Skin	1.33E-13	2.80E-01	6.10E-01
Thrombocythemia	3B63	Whole blood	3.29E-03	1.73E-01	1.07E+00
Thrombocytopenia	3B64	Whole blood	1.54E-01	-3.36E-01	-9.99E-01
Thyroid cancer	2D10	Thyroid	1.99E-02	1.73E-02	7.97E-02
Tibial muscular dystrophy	8C75	Muscle tissue	4.64E-02	-1.04E-01	-6.14E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	8.84E-01	-8.56E-02	-4.64E-01
Type 2 diabetes	5A11	Liver tissue	9.11E-02	-5.85E-02	-5.74E-01
Ureter cancer	2C92	Urothelium	6.84E-01	2.96E-02	1.98E-01
Uterine cancer	2C78	Endometrium tissue	3.60E-21	2.46E-01	1.08E+00
Vitiligo	ED63.0	Skin	2.54E-01	2.73E-01	4.96E-01