Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEHKSC6)

• DME Name: Prostaglandin dehydrogenase 1 (HPGD) DME Info
• Gene Name: HPGD

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	8.66E-06	-9.35E-02	-2.14E-01
Alopecia	ED70	Skin from scalp	1.94E-03	3.52E-01	7.82E-01
Alzheimer's disease	8A20	Entorhinal cortex	5.09E-01	2.66E-02	8.66E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	7.98E-01	-1.50E-01	-2.00E-01
Aortic stenosis	BB70	Calcified aortic valve	6.30E-01	-1.07E-01	-2.62E-01
Apnea	7A40	Hyperplastic tonsil	4.79E-01	1.46E-01	1.06E-01
Arthropathy	FA00-FA5Z	Peripheral blood	7.09E-01	-1.92E-01	-3.77E-01
Asthma	CA23	Nasal and bronchial airway	7.72E-08	1.42E+00	7.70E-01
Atopic dermatitis	EA80	Skin	8.29E-14	-1.69E+00	-5.19E+00
Autism	6A02	Whole blood	2.62E-01	4.72E-02	8.71E-02
Autoimmune uveitis	9A96	Peripheral monocyte	1.08E-01	-2.14E-01	-1.01E+00
Autosomal dominant monocytopenia	4B04	Whole blood	8.36E-02	1.07E+00	2.13E+00
Bacterial infection of gingival	1C1H	Gingival tissue	2.53E-14	-1.10E+00	-1.30E+00
Batten disease	5C56.1	Whole blood	9.93E-01	3.27E-01	9.21E-01
Behcet's disease	4A62	Peripheral blood	3.60E-01	-4.59E-01	-9.28E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	3.03E-01	-6.77E-03	-4.26E-02
Bladder cancer	2C94	Bladder tissue	6.14E-10	-2.99E+00	-5.29E+00
Breast cancer	2C60-2C6Z	Breast tissue	4.67E-06	-5.10E-01	-3.13E-01
Cardioembolic stroke	8B11.20	Whole blood	3.61E-02	2.36E-01	5.11E-01
Cervical cancer	2C77	Cervical tissue	1.89E-04	-1.50E+00	-1.08E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	7.03E-01	-4.69E-02	-6.32E-02
Chronic hepatitis C	1E51.1	Whole blood	1.85E-01	-2.53E-01	-5.43E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	7.80E-02	-3.48E-01	-4.66E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.39E-03	-3.14E-01	-2.86E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.17E-03	-1.82E+00	-1.65E+00
Colon cancer	2B90	Colon tissue	4.43E-139	-3.54E+00	-4.61E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	4.61E-01	1.88E-01	4.62E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	7.36E-01	-4.37E-02	-2.70E-01
Endometriosis	GA10	Endometrium tissue	8.89E-04	-1.60E+00	-7.87E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	6.77E-01	2.92E-01	5.45E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.20E-01	1.16E-01	3.74E-01
Gastric cancer	2B72	Gastric tissue	1.84E-01	-1.45E+00	-1.03E+00
Glioblastopma	2A00.00	Nervous tissue	2.31E-01	-3.52E-02	-9.45E-02
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	8.83E-01	-5.91E-02	-5.45E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	5.61E-02	-4.31E-01	-5.01E-01
Head and neck cancer	2D42	Head and neck tissue	4.28E-21	-1.96E+00	-1.78E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	6.39E-01	-2.85E-02	-2.29E-01
Huntington's disease	8A01.10	Whole blood	9.72E-01	-1.22E-02	-7.26E-02
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	4.87E-01	4.15E-01	5.62E-01
Immunodeficiency	4A00-4A20	Peripheral blood	9.48E-01	2.33E-01	6.51E-01
Influenza	1E30	Whole blood	4.20E-02	4.18E-01	1.94E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.89E-02	-6.27E-01	-1.51E+00
Intracranial aneurysm	8B01.0	Intracranial artery	7.69E-02	6.68E-01	1.20E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	6.20E-01	-1.46E-02	-4.33E-02
Ischemic stroke	8B11	Peripheral blood	1.88E-01	-3.24E-01	-5.84E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	3.95E-05	1.10E-01	2.60E-01
Lateral sclerosis	8B60.4	Skin	4.30E-01	4.32E-02	5.19E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	9.90E-02	8.57E-02	8.47E-01
Liver cancer	2C12.0	Liver tissue	7.83E-24	-2.54E+00	-2.56E+00
Liver failure	DB99.7-DB99.8	Liver tissue	4.59E-05	-3.51E+00	-3.03E+00
Lung cancer	2C25	Lung tissue	1.17E-103	-2.47E+00	-2.71E+00
Lupus erythematosus	4A40	Whole blood	4.53E-04	3.13E-01	4.16E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	7.01E-01	-1.84E-02	-1.21E-01
Major depressive disorder	6A70-6A7Z	Whole blood	9.78E-01	-1.92E-02	-2.55E-02
Melanoma	2C30	Skin	9.39E-01	1.40E-01	8.56E-02
Multiple myeloma	2A83.1	Peripheral blood	4.74E-01	1.99E-01	1.52E-01
Multiple myeloma	2A83.1	Bone marrow	1.14E-02	-2.85E-01	-1.38E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	1.92E-01	-1.92E-01	-6.81E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	1.43E-01	-8.21E-02	-1.23E-01
Myelofibrosis	2A20.2	Whole blood	1.49E-03	-3.52E-01	-1.12E+00
Myocardial infarction	BA41-BA50	Peripheral blood	5.88E-01	-4.47E-01	-5.20E-01
Myopathy	8C70.6	Muscle tissue	9.67E-01	-9.69E-02	-1.42E-01
Neonatal sepsis	KA60	Whole blood	1.12E-20	1.48E+00	1.93E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	2.39E-04	3.73E-02	3.57E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	1.05E-02	1.09E+00	1.61E+00
Obesity related type 2 diabetes	5A11	Omental adipose tissue	2.49E-01	-1.81E-01	-2.83E-01
Olive pollen allergy	CA08.00	Peripheral blood	3.42E-01	6.27E-02	3.68E-01
Oral cancer	2B6E	Oral tissue	1.82E-02	-9.32E-01	-7.36E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	7.52E-01	-2.82E-01	-3.45E-01
Osteoporosis	FB83.1	Bone marrow	1.80E-01	1.05E-01	9.63E-01
Ovarian cancer	2C73	Ovarian tissue	2.14E-01	7.15E-02	6.74E-02
Pancreatic cancer	2C10	Pancreas	2.03E-04	1.73E+00	1.47E+00
Parkinson's disease	8A00.0	Substantia nigra tissue	2.29E-02	-2.84E-01	-5.71E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	4.36E-02	1.18E-01	2.29E-01
Pituitary cancer	2D12	Pituitary tissue	2.15E-01	1.39E-01	1.76E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	2.36E-01	6.57E-01	7.81E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.81E-01	5.63E-02	3.77E-01
Polycythemia vera	2A20.4	Whole blood	3.29E-09	5.23E-01	1.76E+00
Pompe disease	5C51.3	Biceps muscle	2.88E-02	7.40E-01	2.05E+00
Preterm birth	KA21.4Z	Myometrium	2.53E-01	2.31E-01	2.16E-01
Prostate cancer	2C82	Prostate	9.59E-01	1.63E-01	1.59E-01
Psoriasis	EA90	Skin	2.04E-02	-1.23E-01	-2.08E-01
Rectal cancer	2B92	Rectal colon tissue	7.47E-09	-2.54E+00	-6.82E+00
Renal cancer	2C90-2C91	Kidney	3.40E-04	-2.23E+00	-2.40E+00
Retinoblastoma	2D02.2	Uvea	8.86E-02	1.81E-01	6.16E-01
Rheumatoid arthritis	FA20	Synovial tissue	8.34E-02	-6.03E-01	-1.33E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	9.33E-01	6.21E-02	1.05E-01
Schizophrenia	6A20	Prefrontal cortex	8.74E-02	-1.01E-02	-1.04E-02
Schizophrenia	6A20	Superior temporal cortex	9.18E-01	1.76E-02	1.41E-01
Scleroderma	4A42.Z	Whole blood	6.50E-01	2.90E-02	6.21E-02
Seizure	8A60-8A6Z	Whole blood	6.20E-02	4.95E-01	6.65E-01
Sensitive skin	EK0Z	Skin	9.85E-01	-5.16E-02	-1.66E-01
Sepsis with septic shock	1G41	Whole blood	3.14E-75	1.92E+00	2.75E+00
Shwachman-Diamond syndrome	3A70.0	Bone marrow	2.38E-01	3.64E-01	1.07E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	2.58E-01	6.29E-01	9.27E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	9.94E-01	1.03E-02	2.50E-03
Sjogren's syndrome	4A43.2	Salivary gland tissue	7.20E-02	1.93E-01	8.37E-01
Skin cancer	2C30-2C3Z	Skin	1.30E-30	-1.23E+00	-1.93E+00
Thrombocythemia	3B63	Whole blood	3.60E-03	1.08E-01	3.79E-01
Thrombocytopenia	3B64	Whole blood	4.58E-01	-1.86E-01	-2.41E-01
Thyroid cancer	2D10	Thyroid	5.96E-02	-9.55E-02	-1.61E-01
Tibial muscular dystrophy	8C75	Muscle tissue	9.53E-03	6.94E-01	1.02E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	5.72E-01	2.51E-01	1.10E+00
Type 2 diabetes	5A11	Liver tissue	2.76E-01	1.98E-01	8.48E-01
Ureter cancer	2C92	Urothelium	4.63E-01	-1.08E+00	-5.36E-01
Uterine cancer	2C78	Endometrium tissue	1.23E-05	-1.10E+00	-6.67E-01
Vitiligo	ED63.0	Skin	4.08E-01	-9.24E-02	-4.77E-01