Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEV3T4A)

• DME Name: Catechol O-methyltransferase (COMT) DME Info
• Gene Name: COMT

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	2.56E-52	6.77E-01	2.52E+00
Alopecia	ED70	Skin from scalp	1.05E-01	-8.93E-02	-2.59E-01
Alzheimer's disease	8A20	Entorhinal cortex	5.00E-03	9.63E-02	4.48E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	7.25E-01	-1.90E-02	-9.88E-02
Aortic stenosis	BB70	Calcified aortic valve	9.33E-01	-1.93E-02	-5.56E-02
Apnea	7A40	Hyperplastic tonsil	1.15E-01	-1.80E-01	-5.35E-01
Arthropathy	FA00-FA5Z	Peripheral blood	7.19E-01	-3.17E-02	-2.59E-01
Asthma	CA23	Nasal and bronchial airway	1.66E-03	-9.86E-03	-1.48E-02
Atopic dermatitis	EA80	Skin	2.52E-01	4.58E-02	1.61E-01
Autism	6A02	Whole blood	8.73E-01	5.66E-03	2.54E-02
Autoimmune uveitis	9A96	Peripheral monocyte	9.39E-02	-5.07E-01	-1.40E+00
Autosomal dominant monocytopenia	4B04	Whole blood	7.52E-01	-1.79E-02	-6.27E-02
Bacterial infection of gingival	1C1H	Gingival tissue	2.37E-01	6.37E-02	2.36E-01
Batten disease	5C56.1	Whole blood	3.49E-01	5.55E-02	3.12E-01
Behcet's disease	4A62	Peripheral blood	5.34E-01	1.35E-01	5.13E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	7.70E-01	-2.74E-02	-1.75E-01
Bladder cancer	2C94	Bladder tissue	3.31E-01	3.45E-03	1.92E-02
Breast cancer	2C60-2C6Z	Breast tissue	2.76E-14	-2.05E-01	-5.59E-01
Cardioembolic stroke	8B11.20	Whole blood	1.55E-07	-3.33E-01	-2.09E+00
Cervical cancer	2C77	Cervical tissue	5.81E-02	-1.50E-01	-4.91E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	2.54E-01	1.16E-01	2.99E-01
Chronic hepatitis C	1E51.1	Whole blood	2.95E-01	3.38E-02	1.70E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	2.98E-01	-6.93E-02	-2.47E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	7.20E-01	2.55E-03	1.11E-02
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	7.13E-01	-6.12E-02	-2.79E-01
Colon cancer	2B90	Colon tissue	1.42E-18	2.36E-01	9.85E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	5.47E-01	3.38E-01	9.38E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	5.25E-01	-6.20E-02	-3.04E-01
Endometriosis	GA10	Endometrium tissue	3.16E-01	1.66E-01	4.19E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	6.54E-01	2.04E-02	1.32E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.76E-09	6.92E-01	1.92E+00
Gastric cancer	2B72	Gastric tissue	3.16E-01	-1.23E-01	-1.00E+00
Glioblastopma	2A00.00	Nervous tissue	1.12E-10	1.41E-01	4.21E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	9.60E-01	-5.65E-02	-2.16E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	6.93E-04	4.66E-01	1.44E+00
Head and neck cancer	2D42	Head and neck tissue	9.70E-02	8.17E-02	2.86E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	8.43E-01	2.94E-02	1.42E-01
Huntington's disease	8A01.10	Whole blood	4.19E-01	-4.26E-02	-1.44E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.57E-01	9.15E-02	4.41E-01
Immunodeficiency	4A00-4A20	Peripheral blood	2.75E-01	4.17E-02	5.73E-01
Influenza	1E30	Whole blood	6.10E-02	1.65E-01	1.95E+00
Interstitial cystitis	GC00.3	Bladder tissue	4.72E-03	-5.64E-01	-2.51E+00
Intracranial aneurysm	8B01.0	Intracranial artery	1.01E-02	4.09E-01	1.32E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	1.23E-02	-2.35E-01	-6.35E-01
Ischemic stroke	8B11	Peripheral blood	2.37E-01	-1.05E-01	-5.95E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.27E-04	-3.32E-01	-8.63E-01
Lateral sclerosis	8B60.4	Skin	6.98E-01	-2.39E-02	-1.14E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	5.27E-01	-6.40E-02	-2.84E-01
Liver cancer	2C12.0	Liver tissue	1.46E-09	-7.19E-01	-1.41E+00
Liver failure	DB99.7-DB99.8	Liver tissue	7.15E-01	8.01E-03	2.57E-02
Lung cancer	2C25	Lung tissue	5.91E-55	-4.80E-01	-1.87E+00
Lupus erythematosus	4A40	Whole blood	1.04E-01	-9.87E-02	-3.94E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	4.34E-01	-7.97E-02	-5.31E-01
Major depressive disorder	6A70-6A7Z	Whole blood	4.90E-01	-3.81E-02	-1.21E-01
Melanoma	2C30	Skin	7.68E-02	-2.81E-01	-4.39E-01
Multiple myeloma	2A83.1	Peripheral blood	7.05E-01	-1.75E-01	-4.72E-01
Multiple myeloma	2A83.1	Bone marrow	2.67E-01	1.11E-01	6.63E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	9.53E-01	-5.26E-02	-2.33E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	8.37E-01	1.61E-01	3.82E-01
Myelofibrosis	2A20.2	Whole blood	1.43E-03	-9.00E-02	-7.70E-01
Myocardial infarction	BA41-BA50	Peripheral blood	3.10E-01	6.42E-02	2.34E-01
Myopathy	8C70.6	Muscle tissue	1.11E-02	1.95E-01	1.31E+00
Neonatal sepsis	KA60	Whole blood	1.60E-05	1.48E-01	5.71E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.89E-07	-9.23E-01	-3.71E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	1.83E-01	1.58E-01	3.06E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	2.72E-01	2.09E-01	8.78E-01
Olive pollen allergy	CA08.00	Peripheral blood	4.45E-03	2.76E-01	2.11E+00
Oral cancer	2B6E	Oral tissue	1.85E-03	-2.24E-01	-5.92E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	3.54E-01	2.94E-01	3.05E-01
Osteoporosis	FB83.1	Bone marrow	3.49E-02	3.98E-01	1.58E+00
Ovarian cancer	2C73	Ovarian tissue	1.37E-02	-2.67E-01	-9.61E-01
Pancreatic cancer	2C10	Pancreas	4.28E-04	1.55E-01	9.30E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	9.24E-02	1.66E-01	1.09E+00
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	2.72E-03	1.52E-01	1.03E+00
Pituitary cancer	2D12	Pituitary tissue	2.97E-04	3.20E-01	1.71E+00
Pituitary gonadotrope tumour	2D12	Pituitary tissue	2.14E-03	3.64E-01	1.66E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.90E-01	5.54E-02	3.90E-01
Polycythemia vera	2A20.4	Whole blood	1.46E-04	-1.08E-01	-7.18E-01
Pompe disease	5C51.3	Biceps muscle	8.67E-01	-7.96E-02	-3.64E-01
Preterm birth	KA21.4Z	Myometrium	5.89E-01	1.16E-01	3.11E-01
Prostate cancer	2C82	Prostate	9.18E-05	-6.21E-01	-1.16E+00
Psoriasis	EA90	Skin	1.68E-08	-1.23E-01	-4.31E-01
Rectal cancer	2B92	Rectal colon tissue	7.79E-01	-2.64E-02	-8.37E-02
Renal cancer	2C90-2C91	Kidney	6.24E-03	-4.31E-01	-1.20E+00
Retinoblastoma	2D02.2	Uvea	1.89E-03	7.71E-01	3.60E+00
Rheumatoid arthritis	FA20	Synovial tissue	5.35E-07	1.16E+00	5.81E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	5.11E-01	3.63E-02	2.64E-01
Schizophrenia	6A20	Prefrontal cortex	1.82E-01	3.02E-02	1.12E-01
Schizophrenia	6A20	Superior temporal cortex	1.25E-01	-4.21E-02	-2.89E-01
Scleroderma	4A42.Z	Whole blood	8.75E-01	-2.69E-02	-2.49E-01
Seizure	8A60-8A6Z	Whole blood	4.90E-01	-1.89E-02	-1.45E-01
Sensitive skin	EK0Z	Skin	8.05E-01	-4.37E-02	-3.55E-01
Sepsis with septic shock	1G41	Whole blood	8.27E-05	4.70E-02	2.38E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	2.92E-02	-2.47E-01	-1.82E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	4.19E-01	1.90E-01	7.36E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	7.20E-01	1.06E-01	2.79E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	8.48E-01	-8.53E-02	-3.72E-01
Skin cancer	2C30-2C3Z	Skin	2.16E-17	-3.72E-01	-1.02E+00
Thrombocythemia	3B63	Whole blood	8.08E-02	-1.34E-01	-1.10E+00
Thrombocytopenia	3B64	Whole blood	4.43E-01	4.48E-01	4.47E-01
Thyroid cancer	2D10	Thyroid	1.91E-02	2.97E-02	1.05E-01
Tibial muscular dystrophy	8C75	Muscle tissue	9.11E-01	-8.22E-02	-2.97E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.55E-01	3.93E-01	2.35E+00
Type 2 diabetes	5A11	Liver tissue	9.27E-01	6.45E-02	2.23E-01
Ureter cancer	2C92	Urothelium	7.95E-01	4.61E-02	1.85E-01
Uterine cancer	2C78	Endometrium tissue	3.79E-09	-1.79E-01	-4.03E-01
Vitiligo	ED63.0	Skin	6.75E-03	9.15E-02	1.14E+00