Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEVXTP5)

• DME Name: Hypoxanthine phosphoribosyltransferase (HPRT1) DME Info
• Gene Name: HPRT1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.78E-02	3.32E-02	1.68E-01
Alopecia	ED70	Skin from scalp	3.72E-01	-3.59E-03	-2.35E-02
Alzheimer's disease	8A20	Entorhinal cortex	2.90E-07	-2.53E-01	-6.95E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	6.60E-01	1.13E-01	7.35E-01
Aortic stenosis	BB70	Calcified aortic valve	8.12E-01	2.32E-02	3.46E-02
Apnea	7A40	Hyperplastic tonsil	2.49E-01	-1.19E-01	-3.47E-01
Arthropathy	FA00-FA5Z	Peripheral blood	1.18E-01	-6.16E-02	-5.17E-01
Asthma	CA23	Nasal and bronchial airway	1.67E-05	6.54E-02	1.23E-01
Atopic dermatitis	EA80	Skin	5.27E-02	5.58E-02	7.22E-01
Autism	6A02	Whole blood	5.37E-01	-4.07E-02	-1.88E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.38E-02	-2.02E-01	-1.27E+00
Autosomal dominant monocytopenia	4B04	Whole blood	8.27E-01	1.15E-01	6.31E-01
Bacterial infection of gingival	1C1H	Gingival tissue	8.90E-07	-1.12E-01	-6.99E-01
Batten disease	5C56.1	Whole blood	3.73E-01	-4.80E-02	-5.43E-01
Behcet's disease	4A62	Peripheral blood	6.18E-01	-4.68E-03	-4.22E-02
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	1.35E-01	-4.83E-02	-2.09E-01
Bladder cancer	2C94	Bladder tissue	1.54E-04	2.59E-01	2.41E+00
Breast cancer	2C60-2C6Z	Breast tissue	8.75E-85	6.23E-01	1.86E+00
Cardioembolic stroke	8B11.20	Whole blood	1.34E-05	1.95E-01	1.25E+00
Cervical cancer	2C77	Cervical tissue	4.84E-06	3.28E-01	1.27E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	8.51E-01	-7.19E-02	-1.66E-01
Chronic hepatitis C	1E51.1	Whole blood	3.88E-01	-5.14E-02	-6.04E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	2.00E-01	-1.02E-01	-4.64E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	7.76E-02	-4.33E-02	-2.45E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.90E-01	1.18E-01	8.50E-01
Colon cancer	2B90	Colon tissue	2.20E-49	4.50E-01	1.84E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	5.66E-01	2.40E-01	8.48E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	2.01E-01	1.73E-01	4.13E-01
Endometriosis	GA10	Endometrium tissue	1.89E-06	-5.37E-01	-1.13E+00
Familial hypercholesterolemia	5C80.00	Peripheral blood	2.87E-02	1.42E-01	1.25E+00
Familial hypercholesterolemia	5C80.00	Whole blood	7.15E-09	5.59E-01	1.77E+00
Gastric cancer	2B72	Gastric tissue	4.08E-01	2.62E-02	3.24E-02
Glioblastopma	2A00.00	Nervous tissue	5.70E-96	-8.02E-01	-1.68E+00
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	1.68E-02	-3.80E-01	-4.43E+00
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.40E-02	5.08E-01	1.27E+00
Head and neck cancer	2D42	Head and neck tissue	1.76E-41	5.59E-01	2.42E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	2.05E-01	-6.33E-01	-1.02E+00
Huntington's disease	8A01.10	Whole blood	1.00E-01	-1.88E-01	-8.71E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	4.52E-01	1.88E-01	8.18E-01
Immunodeficiency	4A00-4A20	Peripheral blood	1.35E-03	1.77E-01	1.68E+00
Influenza	1E30	Whole blood	2.61E-01	-1.85E-01	-9.77E-01
Interstitial cystitis	GC00.3	Bladder tissue	5.05E-03	2.60E-01	2.17E+00
Intracranial aneurysm	8B01.0	Intracranial artery	3.66E-02	1.65E-01	7.76E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	2.11E-01	6.39E-02	3.15E-01
Ischemic stroke	8B11	Peripheral blood	7.34E-01	-8.86E-03	-8.38E-02
Juvenile idiopathic arthritis	FA24	Peripheral blood	4.79E-01	4.20E-02	1.79E-01
Lateral sclerosis	8B60.4	Skin	8.88E-01	1.00E-01	1.17E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	9.84E-01	-6.69E-02	-8.24E-02
Liver cancer	2C12.0	Liver tissue	3.10E-01	2.83E-03	1.23E-02
Liver failure	DB99.7-DB99.8	Liver tissue	1.66E-02	-1.45E-01	-1.16E+00
Lung cancer	2C25	Lung tissue	4.40E-101	5.71E-01	2.74E+00
Lupus erythematosus	4A40	Whole blood	7.88E-01	3.50E-02	1.47E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	8.18E-01	2.72E-02	1.33E-01
Major depressive disorder	6A70-6A7Z	Whole blood	9.47E-01	-1.74E-02	-8.32E-02
Melanoma	2C30	Skin	1.33E-01	9.67E-02	3.76E-01
Multiple myeloma	2A83.1	Peripheral blood	3.83E-01	-6.73E-02	-1.49E-01
Multiple myeloma	2A83.1	Bone marrow	2.20E-07	1.14E+00	6.27E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	9.97E-01	-1.52E-01	-3.38E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	7.08E-01	4.64E-03	3.88E-02
Myelofibrosis	2A20.2	Whole blood	1.92E-01	1.04E-01	5.50E-01
Myocardial infarction	BA41-BA50	Peripheral blood	6.16E-01	-3.77E-02	-1.20E-01
Myopathy	8C70.6	Muscle tissue	2.38E-02	2.64E-01	1.05E+00
Neonatal sepsis	KA60	Whole blood	3.92E-06	1.92E-01	6.90E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	9.95E-04	6.04E-01	1.59E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	4.11E-01	-1.23E-01	-3.73E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	4.90E-01	-1.22E-01	-3.26E-01
Olive pollen allergy	CA08.00	Peripheral blood	8.24E-02	-9.20E-02	-5.93E-01
Oral cancer	2B6E	Oral tissue	1.53E-07	7.72E-01	1.65E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	3.43E-01	1.34E-01	5.93E-01
Osteoporosis	FB83.1	Bone marrow	8.14E-01	5.55E-02	1.94E-01
Ovarian cancer	2C73	Ovarian tissue	2.19E-03	4.90E-01	1.52E+00
Pancreatic cancer	2C10	Pancreas	7.59E-01	-1.33E-03	-8.04E-03
Parkinson's disease	8A00.0	Substantia nigra tissue	1.40E-01	-4.62E-01	-8.16E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	5.04E-05	1.11E-01	1.46E+00
Pituitary cancer	2D12	Pituitary tissue	2.50E-02	1.75E-01	6.12E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	2.56E-02	2.65E-01	1.07E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	7.76E-01	-7.10E-03	-4.10E-02
Polycythemia vera	2A20.4	Whole blood	1.19E-02	-3.60E-02	-1.85E-01
Pompe disease	5C51.3	Biceps muscle	2.76E-01	5.53E-02	3.87E-01
Preterm birth	KA21.4Z	Myometrium	2.70E-01	-1.54E-01	-5.02E-01
Prostate cancer	2C82	Prostate	5.73E-01	-4.06E-02	-1.09E-01
Psoriasis	EA90	Skin	1.57E-03	-5.75E-02	-3.64E-01
Rectal cancer	2B92	Rectal colon tissue	1.79E-04	2.26E-01	2.63E+00
Renal cancer	2C90-2C91	Kidney	1.92E-01	8.74E-02	4.57E-01
Retinoblastoma	2D02.2	Uvea	7.73E-07	-8.26E-01	-8.24E+00
Rheumatoid arthritis	FA20	Synovial tissue	7.63E-01	5.06E-02	2.53E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	4.74E-01	-5.68E-03	-5.17E-02
Schizophrenia	6A20	Prefrontal cortex	3.05E-03	-1.92E-01	-4.99E-01
Schizophrenia	6A20	Superior temporal cortex	4.82E-01	1.55E-02	3.77E-02
Scleroderma	4A42.Z	Whole blood	9.62E-02	6.36E-02	8.67E-01
Seizure	8A60-8A6Z	Whole blood	1.33E-01	2.51E-01	1.12E+00
Sensitive skin	EK0Z	Skin	2.47E-01	6.26E-04	9.49E-03
Sepsis with septic shock	1G41	Whole blood	2.21E-03	8.07E-03	3.18E-02
Shwachman-Diamond syndrome	3A70.0	Bone marrow	2.03E-02	-2.28E-01	-1.47E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	6.55E-01	-1.17E-01	-3.12E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	3.66E-02	2.55E-01	3.35E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	5.21E-05	1.53E-01	9.43E+00
Skin cancer	2C30-2C3Z	Skin	2.17E-07	7.51E-02	3.67E-01
Thrombocythemia	3B63	Whole blood	1.04E-01	-6.88E-03	-3.61E-02
Thrombocytopenia	3B64	Whole blood	4.53E-01	-3.21E-01	-7.02E-01
Thyroid cancer	2D10	Thyroid	2.81E-02	2.16E-02	1.36E-01
Tibial muscular dystrophy	8C75	Muscle tissue	3.17E-03	1.83E-01	9.16E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	7.97E-03	-5.66E-01	-4.82E+00
Type 2 diabetes	5A11	Liver tissue	8.43E-01	-1.99E-01	-5.21E-01
Ureter cancer	2C92	Urothelium	9.75E-01	-1.15E-01	-4.68E-01
Uterine cancer	2C78	Endometrium tissue	4.36E-07	2.43E-01	5.48E-01
Vitiligo	ED63.0	Skin	2.93E-01	-1.07E-02	-9.53E-02