Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DEX2KIA)

• DME Name: Steroid 17-alpha-monooxygenase (CYP17A1) DME Info
• Gene Name: CYP17A1

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.03E-02	5.07E-02	3.70E-01
Alopecia	ED70	Skin from scalp	1.39E-04	1.64E-01	7.81E-01
Alzheimer's disease	8A20	Entorhinal cortex	1.92E-01	6.56E-03	4.68E-02
Ankylosing spondylitis	FA92.0	Pheripheral blood	8.81E-01	-1.05E-02	-1.16E-01
Aortic stenosis	BB70	Calcified aortic valve	5.35E-01	8.56E-02	2.37E-01
Apnea	7A40	Hyperplastic tonsil	7.85E-02	-1.82E-01	-1.19E+00
Arthropathy	FA00-FA5Z	Peripheral blood	5.72E-01	2.67E-02	1.72E-01
Asthma	CA23	Nasal and bronchial airway	7.51E-02	-7.69E-02	-2.01E-01
Atopic dermatitis	EA80	Skin	1.32E-01	-6.74E-02	-8.12E-01
Autism	6A02	Whole blood	2.97E-01	-4.94E-02	-2.93E-01
Autoimmune uveitis	9A96	Peripheral monocyte	1.13E-02	-1.30E-01	-1.45E+00
Autosomal dominant monocytopenia	4B04	Whole blood	4.15E-01	4.60E-02	5.27E-01
Bacterial infection of gingival	1C1H	Gingival tissue	1.29E-01	4.11E-02	2.17E-01
Batten disease	5C56.1	Whole blood	7.22E-02	6.92E-02	5.51E-01
Behcet's disease	4A62	Peripheral blood	5.29E-01	9.97E-02	5.74E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	6.61E-01	-3.66E-02	-3.31E-01
Bladder cancer	2C94	Bladder tissue	2.48E-04	3.44E-01	1.93E+00
Breast cancer	2C60-2C6Z	Breast tissue	2.29E-05	-8.31E-02	-3.09E-01
Cardioembolic stroke	8B11.20	Whole blood	9.87E-02	1.62E-01	4.83E-01
Cervical cancer	2C77	Cervical tissue	3.32E-01	-8.99E-03	-5.15E-02
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	7.70E-01	-5.12E-02	-2.64E-01
Chronic hepatitis C	1E51.1	Whole blood	9.22E-01	9.87E-02	5.57E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	2.81E-01	3.59E-04	2.68E-03
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.10E-02	1.07E-01	6.73E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	6.16E-01	-2.18E-02	-2.95E-01
Colon cancer	2B90	Colon tissue	2.87E-04	-3.96E-02	-1.97E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	1.40E-01	-3.00E-01	-1.77E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	3.86E-02	-1.20E-01	-7.85E-01
Endometriosis	GA10	Endometrium tissue	6.43E-02	6.11E-02	2.79E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	5.51E-01	4.69E-02	2.30E-01
Familial hypercholesterolemia	5C80.00	Whole blood	1.96E-02	-1.11E-01	-7.01E-01
Gastric cancer	2B72	Gastric tissue	9.61E-01	4.25E-02	1.24E-01
Glioblastopma	2A00.00	Nervous tissue	3.25E-21	-1.29E-01	-6.19E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	7.69E-01	7.86E-02	2.74E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	1.71E-04	-1.27E+00	-2.00E+00
Head and neck cancer	2D42	Head and neck tissue	1.26E-01	-4.31E-02	-2.61E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	5.98E-02	-8.02E-02	-7.46E-01
Huntington's disease	8A01.10	Whole blood	2.90E-01	8.80E-02	5.81E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.00E-01	-1.76E-02	-8.18E-02
Immunodeficiency	4A00-4A20	Peripheral blood	6.10E-01	3.60E-02	4.29E-01
Influenza	1E30	Whole blood	3.98E-03	4.02E-01	3.62E+00
Interstitial cystitis	GC00.3	Bladder tissue	8.29E-01	1.50E-02	8.25E-02
Intracranial aneurysm	8B01.0	Intracranial artery	2.68E-01	7.42E-02	4.55E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	1.75E-01	7.09E-02	3.08E-01
Ischemic stroke	8B11	Peripheral blood	6.33E-02	8.10E-02	8.61E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	8.49E-03	1.73E-01	5.18E-01
Lateral sclerosis	8B60.4	Skin	1.00E-01	5.90E-02	1.40E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	9.17E-02	7.23E-02	6.09E-01
Liver cancer	2C12.0	Liver tissue	2.96E-04	-1.28E-01	-4.75E-01
Liver failure	DB99.7-DB99.8	Liver tissue	7.37E-03	-1.80E-01	-1.34E+00
Lung cancer	2C25	Lung tissue	6.79E-09	-8.61E-02	-5.17E-01
Lupus erythematosus	4A40	Whole blood	8.00E-01	1.17E-02	5.24E-02
Major depressive disorder	6A70-6A7Z	Hippocampus	7.70E-01	1.64E-02	1.48E-01
Major depressive disorder	6A70-6A7Z	Whole blood	5.13E-01	-5.93E-02	-1.76E-01
Melanoma	2C30	Skin	1.17E-01	-9.92E-02	-2.23E-01
Multiple myeloma	2A83.1	Peripheral blood	5.58E-01	-8.23E-02	-4.60E-01
Multiple myeloma	2A83.1	Bone marrow	2.93E-01	-7.68E-02	-3.97E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	7.72E-01	-5.21E-03	-3.05E-02
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	8.47E-01	2.37E-02	1.23E-01
Myelofibrosis	2A20.2	Whole blood	9.46E-01	3.11E-03	2.06E-02
Myocardial infarction	BA41-BA50	Peripheral blood	1.06E-01	8.82E-02	2.49E-01
Myopathy	8C70.6	Muscle tissue	1.54E-02	-1.93E-01	-1.69E+00
Neonatal sepsis	KA60	Whole blood	8.23E-01	-6.27E-04	-3.00E-03
Neuroectodermal tumour	2A00.11	Brain stem tissue	3.16E-04	-4.12E-01	-2.07E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	9.86E-01	-6.90E-02	-4.16E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	1.92E-01	6.33E-02	9.27E-01
Olive pollen allergy	CA08.00	Peripheral blood	8.33E-01	2.32E-02	1.35E-01
Oral cancer	2B6E	Oral tissue	1.02E-06	-2.79E-01	-1.30E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	1.58E-01	-9.59E-02	-2.94E-01
Osteoporosis	FB83.1	Bone marrow	7.17E-01	-5.90E-02	-5.86E-01
Ovarian cancer	2C73	Ovarian tissue	8.13E-02	-1.93E-01	-1.10E-01
Pancreatic cancer	2C10	Pancreas	1.41E-01	-1.02E-01	-4.58E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	4.76E-01	1.56E-03	8.86E-03
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	2.51E-01	-8.00E-02	-7.16E-01
Pituitary cancer	2D12	Pituitary tissue	8.11E-01	5.26E-02	1.05E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	3.20E-01	8.67E-02	4.28E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	1.97E-01	-6.18E-02	-5.14E-01
Polycythemia vera	2A20.4	Whole blood	3.05E-01	5.98E-02	4.27E-01
Pompe disease	5C51.3	Biceps muscle	4.28E-05	-9.69E-01	-2.34E+00
Preterm birth	KA21.4Z	Myometrium	6.29E-01	-6.54E-02	-3.98E-01
Prostate cancer	2C82	Prostate	6.87E-01	7.13E-02	2.06E-01
Psoriasis	EA90	Skin	4.62E-02	5.45E-02	2.76E-01
Rectal cancer	2B92	Rectal colon tissue	1.97E-01	-1.41E-01	-9.39E-01
Renal cancer	2C90-2C91	Kidney	1.90E-03	-1.34E+00	-1.48E+00
Retinoblastoma	2D02.2	Uvea	1.32E-08	-4.61E-01	-3.77E+00
Rheumatoid arthritis	FA20	Synovial tissue	1.15E-01	-7.78E-02	-2.06E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	2.32E-01	-2.52E-02	-2.28E-01
Schizophrenia	6A20	Prefrontal cortex	8.90E-02	4.30E-02	2.27E-01
Schizophrenia	6A20	Superior temporal cortex	4.15E-01	-5.15E-02	-6.86E-01
Scleroderma	4A42.Z	Whole blood	1.24E-01	8.80E-02	5.89E-01
Seizure	8A60-8A6Z	Whole blood	5.32E-01	2.44E-02	1.11E-01
Sensitive skin	EK0Z	Skin	1.96E-01	6.51E-02	5.39E-01
Sepsis with septic shock	1G41	Whole blood	3.00E-03	1.13E-01	5.01E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	8.07E-01	-2.37E-02	-1.62E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	4.32E-02	1.80E-01	8.73E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	5.42E-01	1.54E-01	4.07E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	1.12E-02	-2.43E-01	-4.30E+00
Skin cancer	2C30-2C3Z	Skin	1.89E-08	-1.51E-01	-5.89E-01
Thrombocythemia	3B63	Whole blood	4.64E-01	3.41E-02	2.11E-01
Thrombocytopenia	3B64	Whole blood	4.92E-01	1.32E-01	5.22E-01
Thyroid cancer	2D10	Thyroid	1.16E-20	-3.84E-01	-1.53E+00
Tibial muscular dystrophy	8C75	Muscle tissue	2.51E-05	-2.92E-01	-2.29E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	4.12E-01	1.33E-01	1.08E+00
Type 2 diabetes	5A11	Liver tissue	9.19E-01	-2.70E-02	-1.81E-01
Ureter cancer	2C92	Urothelium	9.27E-01	-9.12E-02	-5.27E-01
Uterine cancer	2C78	Endometrium tissue	4.94E-03	7.13E-02	3.38E-01
Vitiligo	ED63.0	Skin	9.40E-01	2.25E-02	1.12E-01