Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE6TYUK)

DME Name	Aldosterone synthase (CYP11B2) DME Info
Gene Name	CYP11B2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[1]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[2]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
deoxycorticosterone	DMW6YLS	Discovery agent	N.A.	Investigative	[3]
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Molecule Interaction Atlas

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References

1	Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis. J Med Chem. 2005 Oct 20;48(21):6632-42.
2	Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33.
3	Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1. Biochemistry. 2002 Feb 19;41(7):2311-21.