Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEBS639)

• DME Name: Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info
• Gene Name: CYP27A1

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxercalciferol	DM6FG1P	Chronic kidney disease	GB61	Approved	[1]
Vitamin D	DMWQUC9	N. A.	N. A.	Approved	[2]
Alfacalcidol	DM1237M	Hyperparathyroidism	5A51	Phase 4	[3]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[4]

References

• [1] Efficacy and safety of oral doxercalciferol in the management of secondary hyperparathyroidism in chronic kidney disease stage 4. Indian J Nephrol. 2013 Jul;23(4):271-5.
• [2] Chemoprevention of prostate cancer by cholecalciferol (vitamin D3): 25-hydroxylase (CYP27A1) in human prostate epithelial cells. Clin Exp Metastasis. 2005;22(3):265-73.
• [3] Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development. Biochim Biophys Acta. 2002 Feb 28;1580(2-3):133-44.
• [4] Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20.